63558-65-6

Basic information

• Product Name: 4-Chloro-5-iodopyrimidine
• Synonyms: 4-Chloro-5-iodopyrimidine;4-HYDROXYBENZENSULFONIC ACID SODIUM;4-Chloro-5-iodo-pyriMidine 97%;4-Chloro-5-iodopyriMidine, 95+%
• CAS NO: 63558-65-6
• Molecular Formula: C₄H₂ClIN₂
• Molecular Weight: 240.43
• Product Categories: APIs & Intermediate;Pyrimidine;Pyrimidines;Heterocycle-Pyrimidine series
• Mol File: 63558-65-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 63-65 °C
• Boiling Point: 275.014 °C at 760 mmHg
• Flash Point: 120.125 °C
• Appearance: /
• Density: 2.188 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: -1.35±0.16(Predicted)
• CAS DataBase Reference: 4-Chloro-5-iodopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-5-iodopyrimidine(63558-65-6)
• EPA Substance Registry System: 4-Chloro-5-iodopyrimidine(63558-65-6)

Safety Data

• Hazardous Substances Data: 63558-65-6(Hazardous Substances Data)

Usage

General Description

4-Chloro-5-iodopyrimidine is a chemical compound with the molecular formula C4H2ClIN2. It is a heterocyclic organic compound and belongs to the class of pyrimidines. This chemical is known for its use as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the preparation of various organic compounds and materials. 4-Chloro-5-iodopyrimidine is a versatile building block in organic synthesis, and its unique reactivity makes it valuable in the production of a wide range of products. Its properties and applications make it a valuable chemical in the field of chemical and pharmaceutical industries.

InChI:InChI:1S/C4H2ClIN2/c5-4-3(6)1-7-2-8-4/h1-2H

Upstream product

• 4349-07-9 4-hydroxy-5-iodopyrimidine 
• 4349-07-9 5-iodo-4-(3H)-pyrimidinone 

Downstream Products

• 845658-42-6 4-chloro-5-[(E)-2-phenylethenyl]pyrimidine 
• 845658-32-4 2-benzyl-N-(5-iodopyrimidin-4-yl)-1H-benzimidazol-5-amine 
• 845658-34-6 2-benzyl-N-(5-iodopyrimidin-4-yl)-1,3-benzothiazol-5-amine hydrochloride 
• 1139879-57-4 N-(5-iodopyrimidin-4-yl)-L-4-(N,N-dimethylcarbamyloxy)phenylalanine tert-butyl ester 
• 746677-53-2 N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-5-iodopyrimidin-4-amine 

Relevant articles and documents

4-Anilino-pyrimidine, novel aldosterone synthase (CYP11B2) inhibitors bearing pyrimidine structures

2,2,2-Trifluoro-1-{4-[(4-fluorophenyl)amino]pyrimidin-5-yl}-1-[1-(methylsulfonyl)piperidin-4-yl]ethanol 1 was identified as a novel potent aldosterone synthase inhibitor. Despite large species differences, compound 1 inhibits both human and rodent CYP11B2 in a nano-molar range.

Hetero-aromatic compound and its use in medicine

The invention provides a hetero-aromatic compound or a stereisomer, geometric isomer, tautomer, despinner, nitrogen oxide, hydrate, solvate, metabolite, metabolism precursor and pharmaceutically acceptable salt or prodrug thereof, which is used for treating proliferative diseases. The invention also discloses a pharmaceutical composition containing the compound and an application of the compound or pharmaceutical composition thereof in preparation of a medicine for treating proliferative diseases.

Aurora kinase modulators and method of use

The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R1- are defined herein, and synthetic intermediates, which