63562-00-5Relevant academic research and scientific papers
CONTINUOUS PROCESS FOR THE PREPARATION OF GABAPENTIN SALT
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Page/Page column 12-13, (2019/05/02)
The present invention relates to the field of chemistry for the preparation of gabapentin salt of formula (I). More particularly the present invention relates to a continuous process for preparation of gabapentin salt (I) by means of the Hofmann rearrange
PROCESS FOR PREPARING GABAPENTIN
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Page/Page column 19, (2008/06/13)
The present invention provides compositions and methods of preparing gabapentin that includes (a) subjecting cyclohexanediacetic acid monoamide to a Hofmann rearrangement to yield a solution comprising an isocyanate intermediate; (b) hydrolyzing the isocyanate intermediate in the presence of an alkali base to form a gabapentin alkali salt; (c) converting the gabapentin alkali salt to a gabapentin-amine salt in a water-miscible polar solvent; (d) adding a basic or weakly basic ion exchange resin to a solution comprising the gabapentin-amine salt; (e) removing the ion exchange resin from the solution; and (f) concentrating the solution to yield gabapentin.
Cyclic amino acids
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, (2008/06/13)
The present invention is concerned with new cyclic amino acids and with the preparation thereof.
