63563-83-7Relevant articles and documents
Tricyclic host for linear anions
Kang, Sung Ok,Day, Victor W.,Bowman-James, Kristin
, p. 8629 - 8636 (2010)
A tricyclic host for anions consisting of two tetraamide monocycles attached by two ethylene chains was designed and synthesized. Structural and binding results indicate that the receptor is selective for linear triatomic anions. Crystallographic data for two hydrated free bases, along with FHF -, N3-, and SO42- complexes indicate that there are at least two preferred gross conformations for the host, one of which possesses pseudo-D2 symmetry and the other pseudo-C2h symmetry. Both FHF- and N3 - are encapsulated in the pseudo-D2 symmetric complex, bridging the two tetraamido macrocyclic halves. The pseudo-C2h octahydrate structure shows an ice-like H-bonded (H2O)6 array of water molecules embedded in the host cavity. The SO4 2- structure has a nearly superimposable host conformation to the octahydrate but with the SO42- anions lying outside the host. Binding studies in DMSO-d6 indicate selectivity for FHF -, with lesser affinity for other inorganic anions.
Trapped bifluoride
Kang, Sung Ok,Powell, Douglas,Day, Victor W.,Bowman-James, Kristin
, p. 1921 - 1925 (2006)
(Figure Presented) The quest is over: A tricyclic amide-based anion receptor has been synthesized by connecting two monocyclic precursors. The receptor is highly selective for the binding of the elusive bifluoride anion HF2-, and the adduct represents the first structural example of an encapsulated bifluoride. The bifluoride lies midway between the two macrocycles making up the tricycle and is held by four hydrogen-bonding contacts with the macrocyclic amides.
Synthesis and coordination properties of an azamacrocyclic Zn(II) chemosensor containing pendent methylnaphthyl groups
Alarcon, Javier,Albelda, M. Teresa,Belda, Raquel,Clares, M. Paz,Delgado-Pinar, Estefania,Frias, Juan C.,Garcia-Espana, Enrique,Gonzalez, Jorge,Soriano, Conxa
, p. 6530 - 6538 (2008)
The synthesis of a polyazamacrocycle constituted by two diethylenetriamine bridges functionalized at their central nitrogen with naphth-2-ylmethyl units and interconnected through 2,6-dimethylpyridine spacers (L1) is reported. The protonation behaviour of the new macrocycle in water and in water-ethanol 70/30 v/v mixed solvent has been examined by means of pH-metric, UV-Vis and steady-state fluorescence techniques. The fluorescence emission is slightly quenched following the deprotonation of the central tertiary amines and more deeply quenched upon deprotonation of the secondary amino groups. pH-Metric titrations show that in water-ethanol 70/30 v/v L1 forms stable mononuclear complexes with the divalent transition and post-transition metal ions Mn 2+, Fe2+, Co2+, Cu2+, Zn 2+, Cd2+, Hg2+ and Pb2+. In the case of Cu2+, Zn2+, Hg2+ and Pb2+, formation of binuclear complexes has also been observed. Steady-state fluorescence emission studies show that while interaction with Cu2+ leads to quenching of the fluorescence emission above pH = 2, interaction with Zn2+, Cd2+, Hg2+ and Pb2+ give rise to enhancements of the fluorescence above pH ca. 5, which is particularly noticeable in the case of Zn2+.
Synthesis of two derivatives of 3,6,9-tri(carboxymethyl)-3,6,9-triazaundecanedioic acid and the stabilities of their complexes with Ca2+, Cu2+, Zn2+, Dy3+ and Gd3+
Wang, Yun-Ming
, p. 1083 - 1094 (2000)
Two N-2-hydroxy-1-phenylethyl and N-2-hydroxy-2-phenylethyl derivatives of DTPA (3,6,9-tri(carboxymethyl)-3,6,9-triazaundecanedioic acid), DTPA-H1P = 3,9-di(carboxymethyl)-6-2-hydroxy-1-phenylethyl-3,6,9-triazaundecanedioic acid, and DTPA-H2P = 3,9-di(carboxymethyl)-6-2-hydroxy-2-phenylethyl-3,6,9-triazaundecanedioic acid were synthesized. Their protonation constants were determined by potentiometric titration in 0.10 M Me4NNO3 and by NMR pH titration at 25.0 ± 0.1 °C. The formations of lanthanide(III), copper(II), zinc(II) and calcium(II) complexes were investigated quantitatively by potentiometry. The stability constant for Gd(III) complex is larger than those for Ca(II), Zn(II) and Cu(II) complexes with these two ligands. The selectivity constants and modified selectivity constants of the DTPA-H1P and DTPA-H2P for Gd(III) over endogenously available metal ions were calculated. Comparing pM values at physiological pH 7.4 assesses effectiveness of these two ligands in binding divalent and trivalent metal ions in biological media. The observed water proton relaxivity values of [Gd(DTPA-H1P)] and [Gd(DTPA-H2P)]- became constant with respect to pH changes over the range of 4-10. 17O NMR shifts showed that the [Dy(DTPA-H1P)]- and [Dy(DTPA-H2P)]- complexes at pH 6.30 had 1.91 and 2.28 inner-sphere water molecules, respectively. Water proton spin-lattice relaxation rates of [Gd(DTPA-H1P)]- and [Gd(DTPA-H2P)]- complexes were also consistent with the inner-sphere Gd(III) coordination.
Phthalimide compound and preparation method thereof
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Paragraph 0045; 0056-0061; 0066; 0077-0082; 0083; 0094-0150, (2020/08/27)
The invention relates to a phthalimide compound and a preparation method thereof. The preparation method comprises the following steps that 1, dissolving bis (2-phthalimide) amine, allyl glycidyl ether and sodium hydroxide in cyclohexane to obtain a mixed system A; step 2, reacting the mixed system A at 70-80 DEG C to obtain a mixed system B; and 3, sequentially removing cyclohexane and impuritiesin the mixed system B. Under alkaline conditions, active primary amine at the center of bis (2-phthalimide) amine and allyl glycidyl ether are subjected to a ring-opening reaction; OH easily enables -NH to lose H under alkalinity and high temperature, -NH forms -N with stronger nucleophilicity to attack an epoxy group to open rings, proton H is combined with an O atom of an open-ring epoxy group,-N ions are combined with C atoms, and N-(3-allyloxy-2-hydroxypropyl)-bis (ethyl-2-phthalimide) is prepared.
