63570-02-5

Upstream product

• 6302-55-2 1-(4'-chlorophenyl)-1,3-butanedione 
• 6945-92-2 2-hydrazinyl acetic acid ethyl ester hydrochloride 

Downstream Products

• 1322724-58-2 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-ethylthiosemicarbazide 
• 1322724-59-3 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-cyclohexylthiosemicarbazide 
• 1322724-60-6 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-phenylthiosemicarbazide 
• 1322724-61-7 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-(3-methylphenyl)thiosemicarbazide 
• 1322724-62-8 1-{2-[-5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide 
• 1322724-63-9 1-{2-[-5-(4-chlorophenyl)3-methyl-1H-pyrazol-1-yl]acetyl}-4-(4-nitrophenyl)thiosemicarbazide 
• 1322724-79-7 5-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-ylmethyl]-4-ethyl-2H-1,2,4-triazole-3-thione 
• 1322724-80-0 5-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-ylmethyl]-4-phenyl-2H-1,2,4-triazole-3-thione 
• 1322724-81-1 5-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-ylmethyl]-4-(3-methylphenyl)-2H-1,2,4-triazole-3-thione 
• 1322724-82-2 5-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-ylmethyl]-4-(4-methoxyphenyl)-2H-1,2,4-triazole-3-thione 
• 1322724-40-2 2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl] acetic acid hydrazide 
• 1322724-45-7 5-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl methyl]-3H-1,3,4-oxadiazole-2-thione 

Relevant academic research and scientific papers

Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment

A novel series of thiazolo-pyrazole hybrids has been prepared and assessed for their in vitro COX-1/COX-2 inhibitory activity. Compound 6c exhibited the most selective COX-2 inhibition profile (SI of 264) not far of Celecoxib (2 9 4). In-vivo anti-inflamm