635701-99-4

Basic information

• Product Name: Benzaldehyde, 4-[5-[4-(1,1-dimethylethyl)phenyl]-1,2,4-oxadiazol-3-yl]-
• CAS NO: 635701-99-4
• Molecular Formula: C19H18N2O2
• Molecular Weight: 306.364
• Mol File: 635701-99-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-[5-[4-(1,1-dimethylethyl)phenyl]-1,2,4-oxadiazol-3-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-[5-[4-(1,1-dimethylethyl)phenyl]-1,2,4-oxadiazol-3-yl]-(635701-99-4)
• EPA Substance Registry System: Benzaldehyde, 4-[5-[4-(1,1-dimethylethyl)phenyl]-1,2,4-oxadiazol-3-yl]-(635701-99-4)

Safety Data

• Hazardous Substances Data: 635701-99-4(Hazardous Substances Data)

Upstream product

• 635702-23-7 (E)-N′-hydroxy-4-(hydroxymethyl)benzimidamide 
• 874-89-5 4-Cyanobenzyl alcohol 

Relevant articles and documents

Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3

A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P1) receptor agonists with minimal affinity for the S1P2 and S1P3 receptor subtypes. Analogue 26 (S1P1 IC50 = 0.6 nM) has an excellent pharmacokinetics profile in the rat and dog and is efficacious in a rat skin transplant model, indicating that S1P3 receptor agonism is not a component of immunosuppressive efficacy.

1-((5-ARYL-1,2,4-OXADIAZOL-3-YL)BENZYL)AZETIDINE-3-CARBOXYLATES AND 1-((5-ARYL-1,2,4-OXADIAZOL-3-YL)BENZYL)PYRROLIDINE-3-CARBOXYLATES AS EDG RECEPTOR AGONISTS

The present invention encompasses compounds of Formula I: as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.