635703-89-8Relevant academic research and scientific papers
Efficient and general method for the synthesis of benzopyrans by ethylenediamine diacetate-catalyzed reactions of resorcinols with α,β-unsaturated aldehydes. One step synthesis of biologically active (±)-confluentin and (±)-daurichromenic acid
Lee, Yong Rok,Jung, Hyun Choi,Sang, Heum Yoon
, p. 7539 - 7543 (2007/10/03)
An efficient and general synthesis of benzopyrans is achieved by ethylenediamine diacetate-catalyzed reactions of resorcinols with α,β-unsaturated aldehydes in moderated yields. As an application of this methodology, biologically interesting confluentin, which was known to have an inhibitory effect on histamine release is synthesized in one step. Also, natural daurichromenic acid, which has highly potent anti-HIV activity, is successfully synthesized in one step.
Total Synthesis of the Highly Potent Anti-HIV Natural Product Daurichromenic Acid along with Its Two Chromane Derivatives, Rhododaurichromanic Acids A and B
Kang, Ying,Mei, Yan,Du, Yuguo,Jin, Zhendong
, p. 4481 - 4484 (2007/10/03)
(Equation presented) The highly potent anti-HIV natural product daurichromenic acid was successfully synthesized in only five steps with 49% overall yield. The key step in the synthetic strategy involves a microwave-assisted tandem condensation and intramolecular SN2′- type cyclization to form the 2H-benzopyran core structure.
