635724-46-8

Basic information

• Product Name: (2S)-2-PHENYL-4-OXOPYRROLIDINE, N-BOC PROTECTED
• Synonyms: 4-OXO-2(S)-PHENYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(2S)-2-PHENYL-4-OXOPYRROLIDINE, N-BOC PROTECTED;TERT-BUTYL (2S)-2-PHENYL-4-OXOPYRROLIDINE-1-CARBOXYLATE;(S)-tert-Butyl 4-oxo-2-phenylpyrrolidine-1-carboxylate
• CAS NO: 635724-46-8
• Molecular Formula: C₁₅H₁₉NO₃
• Molecular Weight: 261.32
• Product Categories: Pyrrolidine series;Pyrrolidines;Ring Systems;Heterocyclic Building Blocks
• Mol File: 635724-46-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 385.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.147±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -2.56±0.40(Predicted)
• CAS DataBase Reference: (2S)-2-PHENYL-4-OXOPYRROLIDINE, N-BOC PROTECTED(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-PHENYL-4-OXOPYRROLIDINE, N-BOC PROTECTED(635724-46-8)
• EPA Substance Registry System: (2S)-2-PHENYL-4-OXOPYRROLIDINE, N-BOC PROTECTED(635724-46-8)

Safety Data

• Hazardous Substances Data: 635724-46-8(Hazardous Substances Data)

Usage

General Description

(2S)-2-phenyl-4-oxopyrrolidine, N-BOC protected, is a chemical compound that is commonly used as a building block in organic synthesis. The (2S) indicates that it is a stereoisomer with a specific spatial arrangement of atoms, and the N-BOC group provides protection for the amine functional group, allowing for selective reactions with other functional groups in a molecule. (2S)-2-PHENYL-4-OXOPYRROLIDINE, N-BOC PROTECTED is often used in the creation of pharmaceuticals, agrochemicals, and other fine chemicals, where its unique structure and reactivity can be utilized to create new and useful molecules. Additionally, its BOC protection group allows for controlled reactivity in specific chemical transformations, making it a valuable tool in organic chemistry research and development.

Upstream product

• 635724-49-1 tert-butyl (2S,4S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-phenylpyrrolidine-1-carboxylate 
• 635724-45-7 tert-butyl (2S,4S)-4-hydroxy-2-phenylpyrrolidine-1-carboxylate 

Downstream Products

• 635724-47-9 tert-butyl (2S)-2-phenyl-4-{[(trifluoromethyl)sulfonyl]oxy}-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 639074-56-9 (1S)-1-cyclopropyl-2-[(2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-2-oxoethanamine 
• 635724-48-0 tert-butyl (2S)-2-phenyl-4-(2,5-difluorophenyl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 884902-61-8 4-(2,5-difluoro-phenyl)-2-phenyl-2,5-dihydro-1H-pyrrole 

Relevant articles and documents

Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

The evolution of 2,4-diaryl-2,5-dihydropyrroles as inhibitors of KSP is described. Introduction of basic amide and urea moieties to the dihydropyrrole nucleus enhanced potency and aqueous solubility, simultaneously, and provided compounds that caused mito

Mitotic kinesin inhibitors

The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

MITOTIC KINESIN INHIBITORS

The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to composition