635754-77-7

Upstream product

• 4455-09-8 2-phenylethyl tosylate 
• 179686-45-4 3-(S)-tert-butoxycarbonylamino-4,5,6,7-tetrahydroazepin-2-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 17929-90-7 3-aminoazepan-2-one 

Downstream Products

• 635754-82-4 (RS)-1-(2-phenylethyl)-2-oxo-3-amino-azepine 

Relevant academic research and scientific papers

Facile synthesis of versatile functionalized amino caprolactams using RCM reactions of α-amino acrylamide

We report an efficient synthetic methodology allowing access to functionalized α-amino caprolactams using ring-closing metathesis (RCM). A very high tolerance of α-amino acrylamide RCM precursors toward functional groups is demonstrated. The synthetic pat

Parallel liquid synthesis of N,N′-disubstituted 3-amino azepin-2-ones as potent and specific farnesyl transferase inhibitors

A rapid structure-activity study was performed by parallel liquid synthesis on N,N′-disubstitution of 3-amino azepin-2-one to afford potent and specific farnesyl transferase inhibitors with low nM enzymatic and cellular activities. The activities of the selected compounds were validated in vivo, and compounds 41a and 44a presented significant antitumour activity.