63594-70-7

Upstream product

• 101-61-1 4,4'-methylene-bis(N,N-dimethylaniline) 
• 50-00-0 formaldehyd 
• 16518-62-0 3-bromo-N,N-dimethylaniline 

Downstream Products

• 94722-16-4 3,7-bis(dimethylamino)-5,10-dihydro-5-phenyldibenzophosphorin 
• 1290536-55-8 3,7-bis(N,N-dimethylamino)-5,5-dimethyldibenzo[b,e]silin-10(5H)-one 
• 1393470-88-6 C₃₁H₃₄N₃O₄Si⁽¹⁺⁾ 
• 1426090-17-6 C₃₅H₄₃N₄O₂Si⁽¹⁺⁾*C₂H₃O₂^(1-) 
• 1418275-25-8 C₃₅H₄₃N₄O₂Si⁽¹⁺⁾*C₂H₃O₂^(1-) 
• 1418275-26-9 4-carboxy-2-(7-(dimethylamino)-3-(dimethyliminio)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)benzoate 
• 1418275-28-1 C₃₁H₃₉N₂O₂Si⁽¹⁺⁾*Cl^(1-) 
• 1418275-27-0 SiRMe-6COOH 

Relevant academic research and scientific papers

Nebraska Red: A phosphinate-based near-infrared fluorophore scaffold for chemical biology applications

A series of novel phosphinate-based dyes displaying near-infrared fluorescence (NIR) are reported. These dyes exhibit remarkable photostability and brightness. The phosphinate functionality is leveraged as an additional reactive handle in order to tune ce

Photoresponsive transformation from spherical to nanotubular assemblies: Anticancer drug delivery using macrocyclic cationic gemini amphiphiles

We developed NIR-light-responsive macrocyclic cationic gemini amphiphiles, one of which displayed various favorable properties of lipids. The NIR-light-mediated cleavage of the strained dioxacycloundecine ring led to the conversion of the spherical to a n

Polar fluorescent probe as well as preparation method and application thereof

The invention belongs to the field of fluorescent probes. The invention specifically relates to a polar fluorescent probe and a preparation method and application thereof. In order to solve the problems that a fluorescent probe for detecting polarity thro

Near-infrared silicon-based rhodamine fluorescent dye, preparation method and application of near-infrared silicon-based rhodamine fluorescent dye in mitochondrial meninges in-situ no-clean imaging

The invention provides a near-infrared silicon-based rhodamine fluorescent dye, a preparation method and application of the near-infrared silicon-based rhodamine fluorescent dye in mitochondrialmeninges in-situ wash-free imaging. The structural formula of

Activity-Based Sensing with a Metal-Directed Acyl Imidazole Strategy Reveals Cell Type-Dependent Pools of Labile Brain Copper

Copper is a required nutrient for life and particularly important to the brain and central nervous system. Indeed, copper redox activity is essential to maintaining normal physiological responses spanning neural signaling to metabolism, but at the same time copper misregulation is associated with inflammation and neurodegeneration. As such, chemical probes that can track dynamic changes in copper with spatial resolution, especially in loosely bound, labile forms, are valuable tools to identify and characterize its contributions to healthy and disease states. In this report, we present an activity-based sensing (ABS) strategy for copper detection in live cells that preserves spatial information by a copper-dependent bioconjugation reaction. Specifically, we designed copper-directed acyl imidazole dyes that operate through copper-mediated activation of acyl imidazole electrophiles for subsequent labeling of proximal proteins at sites of elevated labile copper to provide a permanent stain that resists washing and fixation. To showcase the utility of this new ABS platform, we sought to characterize labile copper pools in the three main cell types in the brain: neurons, astrocytes, and microglia. Exposure of each of these cell types to physiologically relevant stimuli shows distinct changes in labile copper pools. Neurons display translocation of labile copper from somatic cell bodies to peripheral processes upon activation, whereas astrocytes and microglia exhibit global decreases and increases in intracellular labile copper pools, respectively, after exposure to inflammatory stimuli. This work provides foundational information on cell type-dependent homeostasis of copper, an essential metal in the brain, as well as a starting point for the design of new activity-based probes for metals and other dynamic signaling and stress analytes in biology.

Silicon incorporation in polymethine dyes

Methods to red-shift fluorophores have garnered considerable interest due to the broad utility of low energy light. The incorporation of silicon into xanthene and coumarin scaffolds has resulted in an array of visible and near-infrared fluorophores. Here,

Rhenium and technetium-complexed silicon rhodamines as near-infrared imaging probes for bimodal SPECT- And optical imaging

Fluorescent Si-rhodamines were modified to enable complexation with the Re(i)- and99mTc(i)-tricarbonyl core. The corresponding complexes exhibit suitable properties as bimodal imaging probes for SPECT- and optical imagingin vitro. Importantly,

NEAR-IR GLUCOSE SENSORS

Glucose-sensing luminescent dyes, polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and systems are provided.

AMINO-SILA-PYRONIN COMPOUND-BASED ONE- OR TWO-PHOTON ABSORPTION FLUORESCENT SUBSTANCE AND USE THEREOF

The present invention relates to a silicon-substituted amino-pyronin compound derivative, a cell- or tissue-imaging method using the same, a cancer diagnosis method using the same, and a method for preparation of the same. More specifically, serving as a

SILICON-SUBSTITUTED RHODAMINE DYES AND DYE CONJUGATES

Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are SiR dyes comprising at least one vinyl group attached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of SiR compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples.