636-19-1

Basic information

• Product Name: N-(4-fluorophenyl)-6-chlorobenzo[d]thiazol-2-amine
• Synonyms: N-(4-fluorophenyl)-6-chlorobenzo[d]thiazol-2-amine
• CAS NO: 636-19-1
• Molecular Weight: 278.737
• Mol File: 636-19-1.mol

Chemical Properties

• CAS DataBase Reference: N-(4-fluorophenyl)-6-chlorobenzo[d]thiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-fluorophenyl)-6-chlorobenzo[d]thiazol-2-amine(636-19-1)
• EPA Substance Registry System: N-(4-fluorophenyl)-6-chlorobenzo[d]thiazol-2-amine(636-19-1)

Safety Data

• Hazardous Substances Data: 636-19-1(Hazardous Substances Data)

Upstream product

• 6828-35-9 5-chloro-2-iodoaniline 
• 1544-68-9 4-fluorophenyl isothiocyanate 
• 63069-48-7 p-chloro-o-iodoaniline 
• 106-47-8 4-chloro-aniline 
• 370-26-3 N-(4-fluorophenyl)-N’-(4-chlorophenyl)thiourea 

Relevant articles and documents

A practical synthesis of 2-aminobenzothiazoles via copper(I)-catalyzed tandem reaction of 2-iodoanilines with isothiocyanates in ionic liquids

A copper(I)-catalyzed tandem reaction of 2-iodoanilines with isothiocyanates was achieved in hydrophobic [bmim][PF6] ionic liquid under mild conditions, generating a variety of 2-aminobenzothiazoles in good to excellent yields. The tandem reaction that was carried out in [bmim][PF6] has some obvious advantages such as accelerated reaction rate and increased yield as compared with the reaction run in volatile solvents such as toluene. Furthermore, the CuI/1,10-phenanthroline catalytic system can be reused up to eight times without loss of activity and efficiency.

Ligand- and solvent-free synthesis of 2-aminobenzothiazoles by copper-catalyzed tandem reaction of 2-haloanilines with isothiocyanates

We report an environmentally friendly, efficient and practical method for the synthesis of 2-aminobenzothiazoles by a copper(II)-catalyzed tandem reaction of 2-haloanilines with isothiocyanates under ligand- and solvent-free conditions in air. The developed methodology conforms to the principles of 'green chemistry' and addresses the shortage of such methods for the synthesis of 2-aminobenzothiazoles. The reaction is quite general and generates a variety of 2-aminobenzothiazoles in good to excellent yields. Copyright

A practical synthesis of 2-aminobenzothiazoles via the tandem reactions of 2-haloanilines with isothiocyanates catalyzed by immobilization of copper in MCM-41

The heterogeneous tandem reactions of 2-haloanilines with isothiocyanates were achieved in DMSO using Et3N as base at 80 °C in the presence of a 3-(2-aminoethylamino)propyl-functionalized MCM-41-immobilized copper(II) complex [MCM-41-2N-CuSO4], yielding a variety of 2- aminobenzothiazoles in good to excellent yields. This heterogeneous copper catalyst exhibited higher activity than CuSO4 and can be recovered and recycled by a simple filtration of the reaction solution and used for at least 10 consecutive trials without any decreases in activity.