636-21-5

Basic information

• Product Name: O-TOLUIDINE HYDROCHLORIDE
• Synonyms: o-Tolidine hydroch;o-ToluidineHCL;ORTHO-TOLUIDINEHCL;ORTHO-TOLUIDINEHYDROCHLORIDE;Prilocaine Related Compound A (100 mg) (o-toluidine hydrochloride);Prilocaine Related CoMpound A;Prilocaine impurity B;O-AMINOTOLUENE HYDROCHLORIDE
• CAS NO: 636-21-5
• Molecular Formula: C₇H₁₀N*Cl
• Molecular Weight: 143.61
• EINECS: 211-252-8
• Product Categories: amine
• Mol File: 636-21-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 215-217 °C(lit.)
• Boiling Point: 242 °C
• Flash Point: 85 °C
• Appearance: White crystalline solid
• Density: 1.0968 (rough estimate)
• Vapor Pressure: 0.325mmHg at 25°C
• Refractive Index: 1.5760 (estimate)
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Stability: Stable. Incompatible with oxidizing agents, alkalies. Light and moisture sensitive.
• BRN: 3558629
• CAS DataBase Reference: O-TOLUIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: O-TOLUIDINE HYDROCHLORIDE(636-21-5)
• EPA Substance Registry System: O-TOLUIDINE HYDROCHLORIDE(636-21-5)

Safety Data

• Hazard Codes: T
• Statements: 45-20/21/22
• Safety Statements: 53-36/37/39-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: XU7350000
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 636-21-5(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

Uses

Different sources of media describe the Uses of 636-21-5 differently. You can refer to the following data:
1. o-Toluidine and o-toluidine hydrochloride are used primarily as intermediates in the manufacture of more than 90 dyes and pigments (NCI 1979, IARC 1982, 2000). They are used in acid-fast dyestuffs, azo pigments and dyes, triarylmethane dyes, sulfur dyes, and indigo compounds and as a photographic dye. o-Toluidine is also used as an intermediate for synthetic rubber and rubber vulcanizing chemicals, pharmaceuticals, and pesticides and as a curing agent in epoxy resin systems. Other minor uses of o-toluidine and its hydrochloride salt are as an intermediate in organic synthesis and as an ingredient in a clinical laboratory reagent for glucose and hemoglobin analyses.
2. o-Toluidine Chloride is a carcinogenic and toxic aromatic amine contained in hair dye, henna and dyed hair samples. Prilocaine USP Related Compound A

General Description

Green crystals or white crystalline solid. Melting point 215-217°F. Highly toxic.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

O-TOLUIDINE HYDROCHLORIDE acts as a weak acid. Incompatible with oxidizing agents and with alkalis .

Fire Hazard

Flash point data for O-TOLUIDINE HYDROCHLORIDE are not available; however, O-TOLUIDINE HYDROCHLORIDE is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also o- TOLUIDINE.

Carcinogenicity

o-Toluidine and o-toluidine hydrochloride are reasonably anticipatedto be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals.

InChI:InChI=1/C7H9N.ClH/c1-6-4-2-3-5-7(6)8;/h2-5H,8H2,1H3;1H

Upstream product

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Downstream Products

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Relevant articles and documents

Cobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides

The commercially available and bench-stable Co(acac)2 ligated with bis[(2-diphenylphosphino)phenyl] ether (dpephos) was employed for selective room temperature hydroboration of nitro compounds with HBPin (TOF up to 4615 h?1), tolerating halide, hydroxy, amino, ether, ester, lactone, amide and heteroaromatic functionalities. These reactions offered a direct access to a variety of N-borylamines RN(H)BPin, which were in situ treated with aldehydes and carboxylic acids to produce a series of aldimines and secondary carboxamides without the need for dehydrating and/or coupling reagents. Combination of these transformations in a sequential one-pot manner allowed for direct and selective synthesis of aldimines and secondary carboxamides from readily available and inexpensive nitro compounds.

Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

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