636-87-3Relevant academic research and scientific papers
Preparation method of phenylephrine hydrochloride impurity standard substance
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Page/Page column 6-16, (2020/09/12)
The invention provides a preparation method of a phenylephrine hydrochloride impurity standard substance, which comprises the following steps: putting an phenylephrine hydrochloride bulk drug under anillumination condition to generate impurities, and obtaining chromatographically pure target impurities by preparative chromatography; in the presence of ketoreductase KRED and reduced coenzyme II NADPH, taking nitromethane and m-hydroxybenzaldehyde as raw materials to react to obtain a concentrate; and finally, recrystallizing the concentrate by using an isopropanol-n-propyl acetate-acetonitrilemixed solution, adding chromatographically pure target impurities neutralized by alkali in the recrystallization process, and salifying to obtain the phenylephrine hydrochloride impurity standard substance (impurity A) which is high in product yield and purity and meets the requirements of drug impurity standard substances.
COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS
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Page/Page column 45-49; 58, (2010/12/31)
The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.
The Resolution and Absolute Configuration by X-Ray Crystallography of the Isomeric Octopamines and Synephrines
Midgley, John M.,Thonoor, Mohan C.,Drake, Alex F.,Williams, Clyde M.,Koziol, Anna E.,Palenik, Gus J.
, p. 963 - 970 (2007/10/02)
Racemates of the naturally occuring biogenic amines, o-, m-, and p-octopamine and p-synephrine, have been resolved by the preparation of suitable diastereomeric salts with antipodes of appropriate organic acids.The circular dichroism (c.d.) curves of (-)-m-octopamine hydrochloride and (-)-m-synephrine hydrochloride were superimposable and of opposite sign to those of the corresponding (-)-p-derivatives.X-ray crystallography of the (-)-3-bromocamphor-8-sulphonate salt of (-)-p-synephrine confirmed (for the first time by direct means in this series of compounds) that the absolute configuration of (-)-p-synephrine is R.It is concluded from the c.d. data that the absolute configuration of (-)-p-octopamine is also R.
