6361-21-3

Usage

Uses

Used in Chemical Synthesis:
2-Chloro-5-nitrobenzaldehyde is used as a key intermediate in the synthesis of various organic compounds, including 5-nitro-2-(1H-pyrrol-1-yl)benzaldehyde. Its reactivity and structural properties make it a valuable building block for creating complex molecules in the field of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Chloro-5-nitrobenzaldehyde is utilized as a starting material for the development of new drugs and medicinal compounds. Its versatile chemical properties allow for the creation of a wide range of therapeutic agents, potentially contributing to the treatment of various diseases and medical conditions.
Used in Dye and Pigment Industry:
2-Chloro-5-nitrobenzaldehyde can also be employed in the dye and pigment industry, where its unique chemical structure and properties can be harnessed to produce a variety of colorants and pigments for various applications, such as textiles, plastics, and printing inks.
Used in Research and Development:
In the field of research and development, 2-Chloro-5-nitrobenzaldehyde serves as an important compound for studying various chemical reactions and mechanisms. Its use in academic and industrial research can lead to the discovery of new synthetic methods, applications, and insights into the behavior of related compounds.

InChI:InChI=1/C7H4ClNO3/c8-7-2-1-6(9(11)12)3-5(7)4-10/h1-4H

Upstream product

• 82679-82-1 N-(2-chloro-5-nitrobenzylidene)-d-10-camphorsulfonamide 
• 25862-09-3 phenylmethyl selenoxide 
• 4346-64-9 selenoanisole 
• 81310-08-9 (-)-(S,S)-3-(2-Chloro-5-nitrophenyl)-2-(d-2-oxo-10-bornylsulfonyl)oxaziridine 
• 81369-89-3 (R,R)-(+)-2-(d-10-camphorsulfonyl)-3-(2-chloro-5-nitrophenyl)oxaziridine 
• 89-98-5 2-chloro-benzaldehyde 
• 80866-80-4 2-chloro-5-nitrobenzyl alcohol 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 102170-92-3 acridin-9-yl-(2-chloro-5-nitro-phenyl)-ketone 
• 107942-65-4 4-nitro-2,4'-oxy-di-benzaldehyde 
• 39119-35-2 5-nitro-2-[N-(p-toluenesulfonyl)amino]benzaldehyde 
• 107915-70-8 3'-methoxy-5-nitro-2,4'-oxy-di-benzaldehyde 
• 52548-32-0 5-nitro-2-phenylsulfanyl-benzaldehyde 
• 319454-73-4 2-(4-bromo-phenylsulfanyl)-5-nitro-benzaldehyde 
• 107942-64-3 5-nitro-2,3'-oxy-di-benzaldehyde 
• 107558-94-1 2-(2-methoxy-phenoxy)-5-nitro-benzaldehyde 
• 34601-40-6 2-dimethylamino-5-nitrobenzaldehyde 
• 71173-78-9 (2-chloro-5-nitro-benzylidene)-isopropyl-amine 
• 20423-20-5 2-chloro-5-nitrobenzaldehyde diethyl acetal 
• 34595-14-7 (2-chloro-5-nitro-benzyliden)-aniline 
• 303058-56-2 N-(2-chloro-5-nitro-benzylidene)-o-toluidine 
• 68827-89-4 (2-chloro-5-nitro-phenyl)-bis-(2-hydroxy-[1]naphthyl)-methane 

Relevant academic research and scientific papers

NEW FYN AND VEGFR2 KINASE INHIBITORS

The invention relates to a N-phenylcarbamoyl compound of Formula (I) or a pharmaceutically acceptable salt thereof for use in the inhibition of at least one of tyrosine kinase selected from Fyn and VEGFR2 in the treatment of diseases and disorders involved with one or both kinases. (Formula)

Monodentate Transient Directing Group Enabled Pd-Catalyzed Ortho-C-H Methoxylation and Chlorination of Benzaldehydes

We report Pd-catalyzed ortho-C-H methoxylation and chlorination of benzaldehydes by employing monodentate transient directing groups (TDGs) as an alternative strategy to bidentate TDGs. More importantly, a single crystal of benzaldehyde imine ortho-cyclopalladium intermediate was successfully obtained, and its structure was unambiguously determined by X-ray diffraction, which clearly showed that it was a binuclear palladium species bridged by a pyridone ligand. The utility of this approach was further demonstrated through the synthesis of key intermediates of natural products and drugs.

Efficient and Highly Selective Solvent-Free Oxidation of Primary Alcohols to Aldehydes Using Bucky Nanodiamond

Selective oxidation of alcohols to aldehydes is widely applicable to the synthesis of various green chemicals. The poor chemoselectivity for complicated primary aldehydes over state-of-the-art metal-free or metal-based catalysts represents a major obstacle for industrial application. Bucky nanodiamond is a potential green catalyst that exhibits excellent chemoselectivity and cycling stability for the selective oxidation of primary alcohols in diverse structures (22 examples, including aromatic, substituted aromatic, unsaturated, heterocyclic, and linear chain alcohols) to their corresponding aldehydes. The results are comparable to reported transition-metal catalysts including conventional Pt/C and Ru/C catalysts for certain substrates under solvent-free conditions. The possible activation process of the oxidant and substrates by the surface oxygen groups and defect species are revealed with model catalysts, ex situ electrochemical measurements, and ex situ attenuated total reflectance. The zigzag edges of sp2 carbon planes are shown to play a key role in these reactions.

9-Benzylidene-9H-fluorene derivatives linked to Monoaza-15-crown-5: Synthesis and metal ion sensing

Two kinds of novel styryl chemosensory 2-FMNC and 3-FMNC, were designed and synthesized by an apporiate introduction of 9-benzylidene-9H-fluorene group as fluorophore with the aim at avoiding photoisomerisation. These 9-benzylidene-9H-fluorene derivatives showed the similar selectivity and sensitivity upon addition of metal ions. The sensitivity of FMNC to alkaline earth metal ions was Ba2+>Sr2+>Ca 2+≈Mg2+. Copyright

Isoquinoline compound melanocortin receptor ligands and methods of using same

The invention relates to melanocortin receptor ligands and methods of using the ligands to alter or regulate the activity of a melanocortin receptor. The invention further relates to tetrahydroisoquinoline aromatic amines that function as melanocortin receptor ligands and as agents for controlling cytokine-regulated physiologic processes and pathologies, and combinatorial libraries thereof.

Purification of 2-chloro-5-nitrobenzaldehyde or acetals thereof

2-chloro-5-nitrobenzaldehyde or an acetal thereof is isolated from a mixture of isomers thereof at a temperature of from -10° to +140° C., by suspending the mixture of isomers in a solvent or solvent mixture.

Process for nucleophilic fluoroalkylation of aldehydes

Aryl difluoromethyl sulfone adds to alkehydes under phase transfer conditions to give novel substituted alcohols of the general formula wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

ASYMMETRIC OXIDATION OF ACHIRAL SELENIDES TO OPTICALLY ACTIVE SELENOXIDES. STEREOCHEMISTRY OF THE ALLYL SELENOXIDE-SELENENATE SIGMATROPIC REARRANGEMENT

Asymmetric oxidation of methyl phenyl selenide (3), under anhydrous conditions, by chiral 2-sulfonyloxaziridines, 1-2, give optically active methyl phenyl selenoxide (8.1-9.3percent ee).The stereochemistry of the selenoxide is determined by the configuration of the oxaziridine three membered ring with nonbonded steric interactions responsible for the chiral recognition.Asymmetric oxidation of E-phenyl cinnamyl selenide (7) by 1-2 affords optically active 1-phenylallyl alcohol (9).A concerted sigmatropic rearrangement via an exo transition state is proposed.