63610-09-3

Basic information

• Product Name: Lodoxamidetromethamine
• Synonyms: Lodoxamidetromethamine;U-42585-E;LodoxaMide troMethaMineon;AlMide;AloMide;LodoxaMide troMetaMol;LodoxaMide troMethaMine salt
• CAS NO: 63610-09-3
• Molecular Formula: C11H6ClN3O6.2C4H11NO3
• Molecular Weight: 553.906
• Product Categories: API
• Mol File: 63610-09-3.mol

Chemical Properties

• Boiling Point: 827.5°C at 760 mmHg
• Flash Point: 454.3°C
• Appearance: /
• Vapor Pressure: 5.22E-29mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: Lodoxamidetromethamine(CAS DataBase Reference)
• NIST Chemistry Reference: Lodoxamidetromethamine(63610-09-3)
• EPA Substance Registry System: Lodoxamidetromethamine(63610-09-3)

Safety Data

• Hazardous Substances Data: 63610-09-3(Hazardous Substances Data)

Usage

Uses

Used in Ophthalmology:
Lodoxamidetromethamine is used as a treatment for ocular disorders such as vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis. It acts as a mast cell stabilizer, inhibiting the release of histamine and other vasoactive products, which helps to alleviate the symptoms of these conditions.
Used in Allergic Conjunctivitis Treatment:
Lodoxamidetromethamine is used as a treatment for allergic conjunctivitis, where it stabilizes mast cells and prevents the release of histamine and other inflammatory mediators, reducing the symptoms of the condition.
Used in Cataract Treatment:
Lodoxamidetromethamine is also used in the treatment of cataracts, although the specific application reason is not provided in the materials.
Used in Antiallergic/Antiasthmatic Research:
Lodoxamidetromethamine is under investigation as an orally active antiallergic/antiasthmatic agent, suggesting potential uses in the treatment of allergic and asthmatic conditions in the future.
Brand names for Lodoxamidetromethamine include Alomide (Alcon) and Almide.

Originator

Upjohn (U.S.A.)

InChI:InChI=1/C11H6ClN3O6.C4H11NO3/c12-7-5(14-8(16)10(18)19)1-4(3-13)2-6(7)15-9(17)11(20)21;5-4(1-6,2-7)3-8/h1-2H,(H,14,16)(H,15,17)(H,18,19)(H,20,21);6-8H,1-3,5H2

Upstream product

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Relevant articles and documents

Preparation method of lodoxamide tromethamine intermediate

The invention belongs to the technical field of medicine chemical engineering, and particularly discloses a preparation method of a lodoxamide tromethamine intermediate of lodoxamide. The method comprises the following steps of (1) dissolving 3,5-diamino-4-chlorobenzonitrile into an organic solvent to form a solution A; (2) dissolving oxalyl chloride into the organic solvent to form a solution B;(3) slowly dripping the solution A into the solution B; in the dripping process, controlling the temperature of the reaction liquid at -20 to 0 DEG C; after the reaction is completed, slowly drippinga certain amount of ice water into the reaction liquid; after the dripping is completed, continuously performing stirring for 0.5 to 1h; then, performing suction filtering; drying obtained filter caketo obtain lodoxamide. The reaction steps of the method are few; the operation is facilitated; the yield is greatly improved and can reach 90 percent or higher; meanwhile, the related impurities of the product lodoxamide are few; the product purity is high; the HPLC purity can reach 99.5 percent or higher; great significance is realized on the synthesis of the lodoxamide tromethamine medicine.