63612-84-0

Upstream product

• 58001-44-8 clavulanic acid 
• 57943-81-4 potassium clavulanate 
• 57943-82-5 methyl clavulanate 
• 79-36-7 dichloroacethyl chloride 
• 57943-84-7 Benzyl Clavulanate 
• 79-43-6 dichloro-acetic acid 

Downstream Products

• 86826-50-8 (5R)-3t-methoxy-7-oxo-3c-vinyl-(5rH)-4-oxa-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester 
• 86826-52-0 (Z)-2-(2-Acetoxy-4-oxo-azetidin-1-yl)-3-hydroxy-penta-2,4-dienoic acid benzyl ester 
• 86826-51-9 (Z)-3-Hydroxy-2-(2-methoxy-4-oxo-azetidin-1-yl)-penta-2,4-dienoic acid benzyl ester 
• 63612-79-3 (2R,5R)-3-[2-Dibenzylamino-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester 
• 63612-81-7 7-oxo-3-vinyl-4-oxa-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzyl ester 
• 86826-53-1 2-Acryloyl-3-hydroxy-5-oxo-pyrrolidine-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Clavulanic Acid and its Derivatives. Structure Elucidation of Clavulanic Acid and the Preparation of Dihydroclavulanic Acid, Isoclavulanic acid, Esters and Related Oxidation Products

Clavulanic acid, a novel β-lactamase inhibitor from Streptomyces clavuligerus, has been shown to be Z-(2R,5R)-3-(β-hydroxyethylidene)-7-oxo-4-oxa-1-azabicycloheptane-2-carboxylic acid (1).The structure and absolute stereochemistry was confirmed by X-ray analysis of the p-nitrobenzyl and p-bromobenzyl esters, (14) and (15).The conversion of clavulanic acid into a variety of esters and acyl derivatives is described.An account of its isomerisation to the E isomer (30) and the formation of an oxetane (45) as a by-product of the photolysis of the phenacyl ester (18) is given.The reduction and oxidation of acid (1) under a variety of conditions has also been examined in detail.

The chemistry of clavulanic acid: Some reactions of esters under neutral, acidic and basic conditions

Investigations into the chemistry of benzyl clavulanate under a variety of reaction conditions has led to acid catalysed one-step conversion to ether and thioether derivatives. Generation of nitrogen-containing displacement products proceeds via the react