63619-66-9

Upstream product

• 111-83-1 1-bromo-octane 
• 29558-77-8 4-bromo-4'-hydroxybiphenyl 
• 629-27-6 1-Iodooctane 
• 92-86-4 4-(4-bromophenyl)bromobenzene 

Downstream Products

• 144099-66-1 2-fluoro-6-octyloxy-3-[4-(4-octyloxyphenyl)phenyl]pyridine 
• 1404213-44-0 C₆₃H₇₆O₃ 
• 1404213-45-1 C₇₄H₈₈O₃Si 
• 1404213-43-9 C₆₁H₇₆O₄ 
• 503425-07-8 1-(4'-Octyloxy-biphenyl-4-yl)-4-pentyl-cyclohexanol 
• 1334511-85-1 Nδ-Boc-Orn(Nα-4''-octyloxy-terphenyl-4-formyl)-Val-Pro-OMe 
• 1334511-80-6 Nδ-Boc-Orn(Nα-4''-octyloxy-terphenyl-4-formyl)-Thr-Pro-OMe 

Relevant academic research and scientific papers

Impact of aggregation on fluorescence sensitivity of molecular probes towards nitroaromatic compounds

We have designed and synthesized three tripods TIBP4, TIBP8 and TIBP12 possessing, respectively, OC4H9, OC8H17 and OC12H25 alkoxy chains on the biphenyl units and have investigated the effect of the chain length on their ease in aggregation and their efficiency in the detection of nitroaromatic compounds. Tripods TIBP8 and TIBP12 self-assemble to form densely populated nano-spheres (60-100 nm) in a water-DMSO (98:2) mixture, as shown by field-emission scanning electron microscopy, transmission electron microscopy and dynamic light scattering studies. TIBP4 which has shorter n-butyl alkyl chains does not undergo aggregation under these conditions. Tripods TIBP8 and TIBP12 which remain in a self-assembled state in water reveal amplified fluorescence quenching with PA, 2,4-DNP, TNT and Cl-DNB, and are associated with NAC induced disaggregation to well-dispersed particles. TIBP8 can detect as low as 10-14 M PA and 2,4-DNP in solution and 2.29 × 10-20 g cm-2 (22.9 zg cm-2) PA by contact mode and is nearly 6000-16000 times more selective towards PA and 2,4-DNP over TNT and Cl-DNB at 20% fluorescence quenching. However, the tripod TIBP12 can detect as low as 10-14 M of each PA, 2,4-DNP, TNT and Cl-DNB and can find application as a general probe for these NACs. TIBP4 which remains in a molecularly dissolved state shows poor sensitivity (LOD 1 nM) towards NACs.

FLUOROALKYLFLUORENE DERIVATIVES

There are provided compounds of the formula D-S1-A-S2-B1 wherein A comprises a 2,7- disubstituted 9,9-fluoroalkyl fluorene diradical of the formula wherein S1, S2, D and B1 have meanings given in the description that are useful as charge transport and emissive materials for the fabrication of electronic devices such as diodes, transistors, and photovoltaic devices.

Non-symmetric dimers comprising chalcone and cholesterol entities: An investigation on structure-property correlations

Four series of new dimers formed by interlinking chalcone and cholesterol mesogenic entities through spacers of varying length and parity have been synthesized and characterized by polarizing optical microscopy, differential scanning calorimetry, X-ray diffraction and electrical switching studies. The structure of the chalcone core has been systematically modified to investigate the effect of the molecular structure on the thermal behaviour of the dimers. The study demonstrates the dramatic dependence of thermal behaviour of these dimers on the nature of the chalcone as well as the length and parity of the spacer. the Partner Organisations 2014.

Total synthesis and structure-activity relationships of caspofungin-like macrocyclic antifungal lipopeptides

The echinocandins represent a well-known class of macrocyclic antifungal lipopeptides that can be used for treatment of invasive fungal infections. Due to their complex chemical structures and synthetic difficulties, the structure-activity relationships (SARs) of them are still limited. A total synthetic approach was developed to synthesize structurally diverse caspofungin-like antifungal cyclic lipopeptides, allowing for systemically investigating their SARs. Most of the designed cyclic lipopeptides showed potent antifungal activities with broad spectrum. In particular, several compounds (e.g., 30a, 30e-h, 31a-d, 32c, and 33a,b) were more active in vitro against Candida albicans or Aspergillus fumigatus than caspofungin. The findings in this work indicated that the 'left' tripeptide segment of cyclic lipopeptide scaffold might be suitable for a hydrophilic structural motif, whereas the 'right' lipotripeptide segment was preferred as a hydrophobic core. The alkoxy-naphthoyl was found to be optimal side chain and alkyl length could affect the SARs of alkoxy-aroyl side chains.

Studies toward the synthesis of phenylacetylene macrocycle based rotaxane precursors as building blocks for organic nanotubes

Synthetic efforts toward the preparation of rotaxane precursors based on phenylacetylene macrocycles (PAM) are described. The aim of this study was to determine the optimal structural parameters to prepare high-molecular-weight rotaxane precursors through a strategy involving two Sonogashira couplings to attach bulky blockers on the PAM core. PAMs with different sizes and functions were prepared and coupled to different blockers to assess whether or not the resulting structure adopts a rotaxane-like conformation in which the rigid rod forms after the Sonogashira coupling threads through the PAM. Copyright

Enantiotropic nematics from cross-like 1,2,4,5-tetrakis(4'-alkyl-4- ethynylbiphenyl)benzenes and their biaxiality studies

The theoretically predicted optimum length/breadth/width ratio for maximizing shape biaxiality was investigated experimentally by the facile and successful synthesis of cross-shaped compound 3, which showed enantiomeric nematic phase behavior. This cross-like core structure could alternatively be viewed as two fused V-shaped mesogens, which have recently immerged as a new direction in biaxial nematic research, at the bending tips that can act as a new structure for biaxial investigations. Whilst the thermal analysis data of compound 3 did not meet the expected theoretical values for biaxial nematics, surface-induced biaxiality was evidenced by optical studies. Cluster-size analysis within the nematic phase of compound 3 revealed the formation of meta-cybotactic nematics, which approached the cluster sizes of cybotactic nematics. The split small-angle 2D X-ray diffraction patterns of magnetic-field-aligned samples indicated that the nematic phase was composed of small smectic C-like clusters with the tilting of molecules within the clusters. The wide-temperature-range enantiomeric nematic phase of cross-like compound 3 enabled the molecular skeleton to serve as an alternative skeleton to bent-rod mesogens, which exhibited nematic phases with the potential competition of transitions to higher-order liquid-crystalline phases and crystallization, for future biaxial investigations. Take up your cross: An enantiotropic nematic phase with a wide temperature range has been achieved by using cross-like mesogens. Biaxiality investigations by using conoscopic and 2D XRD studies imply the formation of small smectic C-like meta-cybotactic clusters in the nematic arrangement. Copyright

Synthesis of liquid crystal molecules based on bis(biphenyl)diacetylene and their liquid crystallinity

We synthesized novel liquid crystalline molecules that contain a bis(biphenyl)diacetylene mesogen and confirmed their structures by 1HNMR, 13CNMR, and FT-IR spectroscopy and mass spectrometry. These compounds formed thermotropic liquid crystals in a wide temperature region that was well characterized by optical microscopic and X-ray measurements.

P-terphenyl derivatives and liquid crystalline compositions

New p-terphenyl derivatives useful as components for preparing practical ferroelectric liquid crystalline compositions and excellent in chemical stability, as well as liquid crystalline compositions containing at least one of the p-terphenyl derivatives.