6362-74-9Relevant articles and documents
Enantioselective hydrogenation of β-dehydroamino acids on a cinchonidine-modified palladium catalyst
Chen, Chunhui,Zhan, Ensheng,Li, Yong,Shen, Wenjie
, p. 117 - 121 (2013/09/23)
Enantioselective hydrogenation of (Z)-β-dehydroamino acids on a cinchonidine-modified Pd/Al2O3 catalyst was explored. Comparative studies by using (Z)-β-dehydroamino acids and esters identified that the carboxylic group in dehydroamino acids was essentially important to get enantioselectivities (33% for aryl substituted and 46% for alkyl substituted β-dehydroamino acids). This result extended the range of enantioselective hydrogenation of α,β-unsaturated carboxylic acids on chirally modified Pd catalysts and offered a new approach to synthesize optically active β-amino acids.
