63633-46-5

Usage

Pyrazole derivative

1H-Pyrazol-3-amine, 4,5-diphenyl- is based on a pyrazole ring, which is a five-membered ring system with two nitrogen atoms.

Amine group attached

The compound has an amine group (-NH2) attached to the pyrazole ring, which can be used in chemical reactions and contributes to the compound's biological activity.

Two phenyl groups at the 4 and 5 positions

The pyrazole ring has two phenyl groups (-Ph) attached at the 4 and 5 positions, which can be used in chemical reactions and contribute to the compound's pharmacological properties.

Potential pharmacological and biological activities

1H-Pyrazol-3-amine, 4,5-diphenylhas potential pharmacological and biological activities, making it a valuable tool in drug discovery and chemical research.

Use in pharmaceutical research and organic synthesis

1H-Pyrazol-3-amine, 4,5-diphenyl- is commonly used in pharmaceutical research and organic synthesis due to its potential pharmacological and biological activities.

Development of new drugs

1H-Pyrazol-3-amine, 4,5-diphenylis used in the development of new drugs, as it can be used as a building block for the synthesis of various organic compounds.

Building block for the synthesis of various organic compounds

The compound can be used as a building block for the synthesis of various organic compounds, making it a valuable tool in chemical research.

Upstream product

• 5415-07-6 3-oxo-2,3-diphenyl-propionitrile 
• 140-29-4 phenylacetonitrile 
• 93-58-3 benzoic acid methyl ester 
• 942227-82-9 3-chloro-4,5-diphenylisothiazole 
• 55185-79-0 5,6-diphenyl-6H-1,3,4-thiadiazin-2-amine 

Downstream Products

• 79833-90-2 7-amino-2,3,6-triphenylpyrazolo<1,5-a>pyrimidine 
• 64781-73-3 3-Diazo-4,5-diphenyl-3H-pyrazol 
• 91120-38-6 10,11-Dihydro-6',7'-diphenylspiro<5H-dibenzocyclohepten-5,3'-<3H>pyrazolo<5,1-c><1,2,4>triazol> 
• 91120-39-7 6,7-Diphenylspiro<3H-pyrazolo<5,1-c>-1,2,4-triazol-3,9'-<9H>-xanthen> 
• 91120-40-0 6',7'-Diphenylspiropyrazolo<5,1-c><1,2,4>triazol>-10-on 
• 91160-13-3 6',7'-Diphenylspiro<9H-fluoren-9,3'-<3H>pyrazolo<5,1-c><1,2,4>triazol> 
• 91120-37-5 3,3,6,7-Tetraphenyl-3H-pyrazolo<5,1-c>-1,2,4-triazol 

Relevant academic research and scientific papers

Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion

The metabolic enzyme methionine adenosyltransferase 2A (MAT2A) was recently implicated as a synthetic lethal target in cancers with deletion of the methylthioadenosine phosphorylase (MTAP) gene, which is adjacent to the CDKN2A tumor suppressor and codelet

INHIBITORS OF CELLULAR METABOLIC PROCESSES

The invention provides inhibitor compounds of MAT2A that are useful as therapeutic agents for treating malignancies wherein the compounds have the general formula (I) : wherein ring A, ring B, ring C and, R1 are as described herein.

Synthesis of pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones

A solid-phase synthesis of 5-aminopyrazole has been developed and applied to the preparation of pyrazolo[5,1-d]-[1,2,3,5]tetrazine-4(3H)-ones. In this strategy, a one-pot reaction from 5-aminopyrazoles to the pyrazolo[5,1-d]-[1,2, 3,5]tetrazine-4(3H)-ones which provided the compounds in good yields was demonstrated. Using this synthetic strategy, we prepared a representative set of 16 pyrazolo[5,1-d][l,2,3,5]tetrazine-4(3H)-ones.

The conversion of isothiazoles into pyrazoles using hydrazine

The conversion of isothiazoles into pyrazoles on treatment with hydrazine is investigated. The influence of various C-3, C-4 and C-5 isothiazole substituents and some limitations of this ring transformation are examined. When the isothiazole C-3 substituent is a good nucleofuge, 3-aminopyrazoles are obtained. However, when the 3-substituent is not a leaving group it is retained in the pyrazole product. Treatment of 4-bromo-3-chloro-5-phenylisothiazole 56 or 3-chloro-4,5-diphenylisothiazole 57 with anhydrous hydrazine at ca. 200 °C for a few minutes gives the corresponding 3-hydrazinoisothiazoles 61 and 64 respectively in high yields; the stability of these new hydrazines is investigated. 5,5′-Diphenyl-3,3′-biisothiazole-4,4′-dicarbonitrile 78 reacts with hydrazine to give 5,5′-diphenyl-3,3′-bi(1H-pyrazole)-4,4′-dicarbonitrile 79. Methylhydrazine reacts with 3-chloro-5-phenylisothiazole-4-carbonitrile 1 to give 3-(1-methylhydrazino)-5-phenylisothiazole-4-carbonitrile 83 and 3-amino-1-methyl-5-phenylpyrazole-4-carbonitrile 84. All products are fully characterised and rational mechanisms for the isothiazole into pyrazole transformation are proposed.

Pyrazolo[1,5-α]pyrimidines: Estrogen receptor ligands possessing estrogen receptor β antagonist activity

In our search for novel subtype-selective estrogen receptor (ER) ligands, we have examined various heterocyclic units as core structural elements. Here, we have investigated the fused, bicyclic pyrazolo[1,5-a]pyrimidine core, which is a system that allows

Pyrazolo[1,5-a]pyrimidines as estrogen receptor ligands: Defining the orientation of a novel heterocyclic core

We investigated the pyrazolo[1,5-a]pyrimidine system as a novel heterocyclic scaffold for the development of estrogen receptor (ER) ligands. By altering the pattern of hydroxyl substitution, we established the orientation that is most favorable for ER bin