63635-30-3Relevant academic research and scientific papers
Synthesis of 5 substituted 2 Oxazolidinethiones and their antagonism to uterotropic effect of diethylstilbestrol
Agrawal,Parmar,Dwivedi,Harbison
, p. 887 - 889 (2007/10/06)
5-(4-Aminophenoxylmethyl)-2-oxazolidinethiones were synthesized by the cyclization of 1-(4-aminophenoxy)-3-amino-2-propanol in the presence of potassium hydroxide and carbon disulfide. This oxazolidinethione, on reaction with suitable isothiocyanates, yielded 5-[4-(substituted thiocarbamido)phenoxymethyl] -2-oxazolidinethiones. These compounds antagonized the uterotropic effects of diethylstilbestrol in female rats and possessed approximate LD50 values of 400->800 mg/kg.
