63636-89-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyridinesulfonamide(6CI,7CI,9CI) is used as a building block for the synthesis of various pharmaceutical compounds due to its unique chemical structure and properties. Its presence in the synthesis process can contribute to the development of new drugs with improved efficacy and reduced side effects.
Used in Chemical Industry:
In the chemical industry, 2-Pyridinesulfonamide(6CI,7CI,9CI) is utilized as a reagent in organic synthesis reactions. Its ability to participate in various chemical transformations makes it a valuable component in the production of a wide range of chemical products.
Used in Medicinal Chemistry Research:
2-Pyridinesulfonamide(6CI,7CI,9CI) is used as a ligand for metal ions in medicinal chemistry research. Its interaction with metal ions can lead to the development of new metal-based drugs with potential therapeutic applications.
Used in Drug Discovery:
As a potential pharmacophore, 2-Pyridinesulfonamide(6CI,7CI,9CI) is employed in drug discovery efforts. Its unique structure and properties can be leveraged to identify and develop new drug candidates with novel mechanisms of action and improved therapeutic profiles.
Further research and studies on 2-Pyridinesulfonamide(6CI,7CI,9CI) may reveal additional potential uses and properties of 2-Pyridinesulfonamide(6CI,7CI,9CI), expanding its applications across various industries and contributing to the advancement of science and medicine.

InChI:InChI=1/C5H6N2O2S/c6-10(8,9)5-3-1-2-4-7-5/h1-4H,(H2,6,8,9)

Upstream product

• 66715-65-9 pyridine-2-sulfonyl chloride 
• 2637-34-5 2-Sulfanylpyridine 
• 99780-72-0 3-mercaptopyridin-2-ylsulfonamide 
• 352-91-0 1-Bromo-3-fluoropropane 
• 16133-25-8 Pyridine-3-sulfonyl chloride 
• 2127-03-9 2,2'-dipyridyldisulphide 
• 109-04-6 2-bromo-pyridine 
• 81745-83-7 pyridin-2-ylzinc(ll) bromide 
• 13939-06-5 molybdenum hexacarbonyl 

Downstream Products

• 19009-75-7 2-Pyridin-sulfonamid-1-oxid 
• 128577-41-3 2-Cyclopentyl-N-{1-[2-methoxy-4-(pyridine-2-sulfonylaminocarbonyl)-benzyl]-1H-indol-6-yl}-acetamide 
• 243467-03-0 C₁₁H₉IN₂O₂S 
• 880470-13-3 [4-(dimethylamino)-2-methoxyphenyl](phenyl)-N-[(2-pyridyl)sulfonyl]methanamine 
• 880470-14-4 (1-methoxy-2-naphthyl)(phenyl)-N-[(2-pyridyl)sulfonyl]methanamine 
• 880470-15-5 (2,4,6-trimethoxyphenyl)(phenyl)-N-[(2-pyridyl)sulfonyl]methanamine 

Relevant academic research and scientific papers

2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

One-pot aerobic oxidative sulfonamidation of aromatic thiols with ammonia by a dual-functional β-MnO2 nanocatalyst

High-surface-area β-MnO2 (β-MnO2-HS) nanoparticles could act as effective heterogeneous catalysts for the one-pot oxidative sulfonamidation of various aromatic and heteroaromatic thiols to the corresponding sulfonamides using molecular oxygen (O2) and ammonia (NH3) as respective oxygen and nitrogen sources, without the need for any additives.

Fe(III)/ l -Valine-Catalyzed One-Pot Synthesis of N -Sulfinyl- and N -Sulfonylimines via Oxidative Cascade Reaction of Alcohols with Sulfinamides or Sulfonamides

An efficient Fe(III), l -valine, and 4-OH-TEMPO catalytic system was found for the oxidation of alcohols followed by condensation with sulfinamide or sulfonamide in one pot for the synthesis of N -sulfinyl- and N- sulfonylimines compounds under mild conditions. This transformation accommodates a variety of substrates, shows high functional-group tolerance, and affords the corresponding products in good to excellent yields.

SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME

ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.

Palladium-Catalyzed Carbonylative Cyclization of Amines via γ-C(sp3)-H Activation: Late-Stage Diversification of Amino Acids and Peptides

The selective γ-C(sp3)-H carbonylation of N-(2-pyridyl)sulfonyl (N-SO2Py)-protected amines has been accomplished by using palladium catalysis and Mo(CO)6 as carbonyl source. The reaction provides a powerful approach for derivatization of amine-based moieties, including amino acids, into richly functionalized γ-lactams. Not only methyl groups, but also methylene C-H bonds of cyclopropanes and conformationally biased molecules can be activated to provide ring-fused γ-lactam derivatives. This carbonylation protocol is also amenable to the late-stage diversification of more-complex multifunctional molecules such as dipeptides and tripeptides, demonstrating the key role of the N-SO2Py as directing group and its capacity to override other inherent substrate coordinating elements. In addition to providing an attractive solution to the difficulties in handling hazardous CO gas, the use of Mo(CO)6 as an air-stable solid source of CO in substoichiometric amount (0.33 equiv) ensures PdII-catalytic activity by preventing its decomposition or deactivation under excess of CO via reduction of PdII to Pd0 or saturation of the metal coordination sphere. Indeed, significantly lower efficiency is observed when the reactions are carried out under CO atmosphere (1 atm), or in the presence of increased amounts of Mo(CO)6. A series of experimental and DFT mechanistic studies provide important insights about the reaction mechanism.

Synthesis of Heteroaryl Sulfonamides from Organozinc Reagents and 2,4,6-Trichlorophenyl Chlorosulfate

A method for the preparation of aryl and heteroaryl sulfonamides using 2,4,6-trichlorophenyl chlorosulfate (TCPC) is described. The reaction of 2-pyridylzinc reagents with TCPC resulted in 2,4,6-trichlorophenyl (TCP) pyridine-2-sulfonates, and the parent pyridine-2-sulfonate was shown to react with amines. Less electron-rich aryl- and heteroarylzinc reagents reacted with TCPC to afford sulfonyl chlorides that were converted in situ to sulfonamides.

Crystal structures of pyridine sulfonamides and sulfonic acids

Despite the widespread occurrence of pyridinesulfonic acid and pyridinesulfonamide functional groups in drugs and pharmaceuticals, and their use as ligands in metal-organic frameworks, a systematic structural study of their hydrogen bonding and molecular packing is lacking. We discuss crystal structures of 2-, 3-, and 4-pyridinesulfonic acids/amides in terms of N +-H???O- hydrogen bonds, N-H???O dimer/catemer synthons, and graph set notations. This model study provides a background for polymorph screening and solid form hunting of pharmacologically active sulfonamides.

Lewis base assisted Bronsted base catalysis: Bidentate phosphine oxides as activators and modulators of bronsted basic lanthanum-aryloxides

(Chemical Equation Presented) Dynamic Duo: A Lewis basic bidentate phosphine oxide was effective for activating and modulating the properties of Bronsted basic lanthanum aryl oxides. The Lewis base 1/lanthanum aryl oxide system was suitable for anti-selective Mannich-type reactions of trichloromethyl ketones (see scheme), affording unique building blocks for azetidine-2-carboxylic acids as well as β-amino acids.

From haloquinolines and halopyridines to quinoline- and pyridinesulfonyl chlorides and sulfonamides

The action of sodium methanethiolate (in boiling DMF) towards haloazines (i.e. chloro- or bromo-pyridines and quinolines) (1) (with halogen substituent in non-aza-activated position) causes sequentially halogen ipso-substitution to methylthioazines (2) and then S-demethylation to azinethiolates (3A), which were: i) subjected to S-methylation, ii) oxidized to diazinyl disulfides (4) and iii) oxidatively chlorinated to azinesulfonyl chlorides (5). α- and γ-pyridine- and quinolinesulfonyl chlorides (5a, 5c, 5d and 5f) were prepared by oxidative chlorination of respective disulfides (4) performed in conc. hydrochloric acid and characterized by 1H and 13C NMR spectra. All azinesulfonyl chlorides (5) were effectively converted to corresponding azinesulfonamides (6).

PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS

The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R 10 and R 20 taken together are formulae (III) and (IV). STR1