6364-00-7 Usage
Uses
Used in Pharmaceutical Research:
N-(4-ethoxyphenyl)naphthalen-1-amine is employed as a key intermediate in the synthesis of various pharmaceuticals, leveraging its unique molecular structure to contribute to the development of novel drugs for addressing diverse medical conditions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, N-(4-ethoxyphenyl)naphthalen-1-amine is used as a building block for designing and discovering new therapeutic agents. Its distinctive properties make it a valuable asset in the creation of innovative pharmaceuticals with improved efficacy and safety profiles.
Used in Drug Development:
N-(4-ethoxyphenyl)naphthalen-1-amine is utilized in the development of new drugs, potentially offering treatments for a range of medical conditions. Its incorporation into drug candidates can enhance their pharmacological activity and selectivity, leading to more effective therapies.
Used in Organic Synthesis:
N-(4-ethoxyphenyl)naphthalen-1-amine also serves as a versatile reactant in organic synthesis, where it can be modified or used as a precursor to create a variety of complex organic molecules with specific applications in different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 6364-00-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,6 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6364-00:
(6*6)+(5*3)+(4*6)+(3*4)+(2*0)+(1*0)=87
87 % 10 = 7
So 6364-00-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H17NO/c1-2-20-16-12-10-15(11-13-16)19-18-9-5-7-14-6-3-4-8-17(14)18/h3-13,19H,2H2,1H3
6364-00-7Relevant academic research and scientific papers
NIXANTPHOS: A highly active ligand for palladium catalyzed Buchwald-Hartwig amination of unactivated aryl chlorides
Mao, Jianyou,Zhang, Jiadi,Zhang, Shuguang,Walsh, Patrick J.
supporting information, p. 8690 - 8696 (2018/07/13)
Xantphos is one of the two most common ligands used in palladium catalyzed Buchwald-Hartwig amination reactions, because of its broad scope and high probability of success. It does not, however, work well with unactivated aryl chlorides. Herein NIXANTPHOS is compared to Xantphos and an array of mono- and bidentate phosphines. NIXANTPHOS outperforms Xantphos and all other bidentate ligands examined. Under the optimal reaction conditions, unactivated aryl chlorides afford the expected products in good to excellent yield with as low as 0.05 mol% (500 ppm) palladium loading.
Manufacture of arylamines
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, (2008/06/13)
Arylamines are manufactured by reacting alcohols with amines in the presence of phosphorus-III compounds. The arylamines I manufactured by the process of the invention are intermediates for the manufacture of crop protection agents, optical brighteners, especially amino-coumarin derivatives, and dyes, especially of the xanthene, pyronine, rhodamine, oxazine, azo, triphenylmethane and diphenylmethane series.
