63648-38-4

Usage

InChI:InChI=1/C14H9NO2/c16-10-15-13-8-6-12(7-9-13)14(17)11-4-2-1-3-5-11/h1-9H

Upstream product

• 26328-59-6 benzophenone 4-isothiocyanate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 1137-41-3 (4-aminophenyl)(phenyl)methanone 
• 611-95-0 4-carboxybenzophenone 
• 134919-56-5 Methyl N-(4-benzoylphenyl)carbamate 

Downstream Products

• 835929-60-7 (4-benzoyl-phenyl)-carbamic acid 3,9,13-tris-(tert-butyl-dimethyl-silanyloxy)-14-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-6-oxo-tetrahydro-pyran-2-yl]-2,4,8,10-tetramethyl-1-(1-methyl-penta-2,4-dienyl)-tetradeca-6,11-dienyl ester 
• 835929-72-1 (4-benzoyl-phenyl)-carbamic acid 3,9,13-tris-(tert-butyl-dimethyl-silanyloxy)-14-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-6-oxo-tetrahydro-pyran-2-yl]-2,4,6,8,10-pentamethyl-1-(1-methyl-penta-2,4-dienyl)-tetradeca-6,11-dienyl ester 
• 1601403-33-1 N-(4-benzoylphenyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamide 
• 1380212-36-1 C₃₆H₃₆N₂O₆ 
• 1380212-33-8 C₃₄H₃₄N₄O₄ 

Relevant academic research and scientific papers

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

Undesirable side effects associated with orthosteric agonists/antagonists of cannabinoid 1 receptor (CB1R), a tractable target for treating several pathologies affecting humans, have greatly limited their translational potential. Recent discovery of CB1R negative allosteric modulators (NAMs) has renewed interest in CB1R by offering a potentially safer therapeutic avenue. To elucidate the CB1R allosteric binding motif and thereby facilitate rational drug discovery, we report the synthesis and biochemical characterization of first covalent ligands designed to bind irreversibly to the CB1R allosteric site. Either an electrophilic or a photoactivatable group was introduced at key positions of two classical CB1R NAMs: Org27569 (1) and PSNCBAM-1 (2). Among these, 20 (GAT100) emerged as the most potent NAM in functional assays, did not exhibit inverse agonism, and behaved as a robust positive allosteric modulator of binding of orthosteric agonist CP55,940. This novel covalent probe can serve as a useful tool for characterizing CB1R allosteric ligand-binding motifs.

1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors

A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50 = 1.15 nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site.

Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide

(Chemical Equation Presented) The design, syntheses, and biological evaluation of 22 totally synthetic analogues of the potent microtubule- stabilizing agent (+)-discodermolide (1) have been achieved. Structure-activity relationships of the C(19) carbamat