63648-90-8Relevant academic research and scientific papers
3-HYDROXY-IMIDAZOLIDIN-4-ONE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE
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Page/Page column 41-42, (2019/03/17)
The invention relates to a compound of Formula (I) : Formula (I), or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of indoleamine 2,3-dioxygenas
Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 1: Substitution of the glycine carboxylic acid group
Amssoms, Katie,Oza, Sandra L.,Ravaschino, Esteban,Yamani, Abdellah,Lambeir, Anne-Marie,Rajan, Padinchare,Bal, Gunther,Rodriguez, Juan Bautista,Fairlamb, Alan H.,Augustyns, Koen,Haemers, Achiel
, p. 2553 - 2556 (2007/10/03)
Glutathionylspermidine synthetase/amidase (GspS) is an essential enzyme in the biosynthesis and turnover of trypanothione and represents an attractive target for the design of selective anti-parasitic drugs. We synthesised a series of analogues of glutathione (L-γ-Glu-L-Leu-Gly-X) where the glycine carboxylic acid group (X) has been substituted for other acidic groups such as tetrazole, hydroxamic acid, acylsulphonamide and boronic acid. The boronic acid appears the most promising lead compound (IC50 of 17.2 μM).
Identification and evaluation of O-alkyl substituted hydroxamic acids as potent in vitro inhibitors of the hepatic glycine cleavage system and investigation of their action on in vivo central nervous system glycine concentration
Johnson,Boxer,Drummond,Boyd,Anderson
, p. 432 - 437 (2007/10/02)
The identification and evaluation of an extensive series of O-alkyl substituted hydroxamic acids as potent in vitro inhibitors of the hepatic glycine cleavage system is described. An investigation of the action of selected examples on the in vitro brain glycine cleavage system and their influence on in vivo plasma and central nervous system glycine concentrations following systemic administration is also reported.
(Substituted)ureidoacetohydroxamic acids
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, (2008/06/13)
A series of (substituted)ureidoacetohydroxamic acids are useful as inhibitors of Angiotensin I converting enzyme.
