63655-40-3

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-1H-BENZIMIDAZOLE-5-CARBONITRILE is used as a building block for the synthesis of various biologically active compounds. Its unique chemical structure allows for the development of new and novel drug candidates with potential therapeutic applications.
Used in Organic Synthesis:
2-AMINO-1H-BENZIMIDAZOLE-5-CARBONITRILE is used as a key intermediate in the synthesis of complex organic molecules. Its carbonitrile functional group at the 5 position provides opportunities for further chemical reactions and modifications, leading to the creation of valuable chemical products.
Further research and development of 2-AMINO-1H-BENZIMIDAZOLE-5-CARBONITRILE could unlock its full potential in these applications and contribute to the advancement of pharmaceuticals and organic synthesis.

InChI:InChI=1/C8H6N4/c9-4-5-1-2-6-7(3-5)12-8(10)11-6/h1-3H,(H3,10,11,12)

Upstream product

• 506-68-3 bromocyane 
• 17626-40-3 4-cyano-1,2-phenylenediamine 
• 6393-40-4 4-Amino 3-nitro-benzonitrile 

Downstream Products

• 1310062-98-6 2-[(4-N,N-diethylamino-2-hydroxy)benzylideneamino]-6-cyanobenzimidazole 
• 1616406-30-4 2-amino-1-(2-(2,3-dichlorophenyl)-2-oxoethyl)-1H-benzo[d]imidazole-5-carbonitrile 
• 1616406-31-5 C₁₆H₁₀Cl₂N₄O 

Relevant academic research and scientific papers

MRGX Receptor Antagonists

The invention relates to a method for preventing or treating a disease or disorder that is associated with the MrgX2 receptor. The invention also relates to MrgX2 antagonists and physiologically acceptable salts thereof. The invention also relates to pharmaceutical compositions and dosage forms comprising an MrgX2 antagonist.

Inhibition and Dispersion of Bacterial Biofilms with 2-Aminobenzimidazole Derivatives

Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those of Pseudomonas and more particularly P. aeruginosa.

2-aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms

Bacterial biofilms are exceptionally difficult to clear using traditional antibiotics and constitute a significant health threat. 2-Aminobenzimidazole derivatives (see scheme) are capable of strongly inhibiting the growth of and dispersing Pseudomonas aeruginosa biofilms. These molecules were found to modulate quorum sensing in reporter strains, and represent some of strongest P. aeruginosa biofilm inhibitors known. Copyright

Synthesis and cytostatic evaluation of pyridopyrimidobenzimidazole derivatives

A set of novel 2,5-substituted benzimidazoles (1-7) and their cyclic derivatives (8-11) were synthesized and evaluated for their potential cytostatic effect on various tumor cell lines. The structures of the synthesized compounds were proved by means of IR, 1H NMR and MS spectral data. Based on presented in vitro screening results we may conclude that cyclic compounds bearing nitro and amino substituents (10 and 11) showed the most pronounced growth inhibitory.

Substituted 1-sulfonylbenzimidazoles

Certain 1-sulfonyl-2,5(6)-substituted-benzimidazole compounds are useful as antiviral agents.