63655-81-2Relevant academic research and scientific papers
Visible Light-Mediated Functionalization of Selenocystine-Containing Peptides
Lapcinska, Sindija,Dimitrijevs, Pavels,Lapcinskis, Linards,Arsenyan, Pavel
, p. 3318 - 3328 (2021)
A straightforward and atom-economic method for the functionalization of short selenocystine-containing peptides is presented. This method is shown to be tolerant to unprotected peptides. The detailed protocol is based on the generation of a selenium radical via visible light-initiated reaction in the presence of transition metal-free photocatalyst. The selenium radical is further oxidized to an electrophile and trapped by N-heterocycles. The mechanism is confirmed by NMR, HRMS, UV, EPR and cyclic voltammetry (CV) experiments and photocatalyst emission quenching studies. A visible light-initiated reaction is employed for the synthesis of selenocysteine-containing indole-based macrocycles via intramolecular Se?C bond formation. (Figure presented.).
Visible Light-Mediated Synthesis of Se?S Bond-Containing Peptides
Arsenyan, Pavel,Dimitrijevs, Pavels,Lapcinska, Sindija
, p. 3968 - 3972 (2021/07/26)
A visible light-initiated method has been developed for preparation of Se?S bond-containing peptides. The method is based on generation of sulfur-centered radical employing organic dye. The protocol is tolerant to unprotected peptides with “sensitive” amino acids. The stability of Se?S bond is evaluated in buffers at different pH (3.0–10.0) and also in the presence of oxidants and reducing agents. Additionally, the ability of Se?S bond to serve as an oxidation sensitive linker in biocompatible materials has been confirmed. (Figure presented.).
Studies on 2-Aziridinecarboxylic Acid. VII. Formation of Dehydroamino Acid Peptides via Isomerization of Peptides Containing 2-Aziridinecarboxylic Acid by Tertiary Amines
Nakajima, Kiichiro,Oda, Hitomi,Okawa, Kenji
, p. 3232 - 3236 (2007/10/02)
Peptides containing 1-(α-aminoacyl)-2-aziridinecarboxylic acid were isomerized into the corresponding dehydroamino acid peptides by treatment with the tertiary amines, triethylamine or 1,4-diazabicyclooctane (Dabco).Dehydrohydantoin derivatives wer
