636589-45-2Relevant academic research and scientific papers
Design and synthesis of highly constrained factor Xa inhibitors: Amidine-Substituted bis(benzoyl)-[1,3]-diazepan-2-ones and bis(benzylidene)-bis(gem-dimethyl)cycloketones
Cui, Jian,Crich, David,Wink, Donald,Lam, Matthew,Rheingold, Arnold L.,Case, David A.,Fu, WenTao,Zhou, Yasheen,Rao, Mohan,Olson, Arthur J.,Johnson, Michael E.
, p. 3379 - 3392 (2007/10/03)
Two conformationally constrained templates have been designed to provide selective inhibitors of the coagulation cascade serine protease, Factor Xa (FXa). The most active inhibitor, 2,7-bis[(Z)-p-amidinobenzylidene)]-3,3,6,6-tetramethylcycloheptanone, exh
