63659-16-5Relevant articles and documents
PROCESS FOR PREPARATION OF PHENOXYPROPANOL AMINES
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Page/Page column 8, (2010/04/06)
The present invention describes an improved method for the preparation of l-[4-{2- (cyclopropylmethoxy)ethyl}phenoxy]-3-[(1-methylethyl)amino]-2-propanol of Formula-(I) and its pharmaceutically acceptable salt, which comprises reacting 4 - [ 2 — (Cyclopropylmethoxy) ethyl] phenol with epichlorohydrin in presence of mild base and polar protic solvent to isolate 1 - {4 - [2 - (cyclopropylmethoxy)ethyl] - phenoxy} - 2, 3 - epoxy propane, which is further reacted with isopropyl amine to get betaxolol formula (I).
PROCESS FOR PREPARATION OF S-(-)-BETAXOLOL AND SALTS THEREOF
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Page/Page column 3-5, (2010/02/15)
The present invention relates to an improved process for preparation of S-(?)-betaxolol salts. More particularly the present invention relates to the preparation of hydrochloride salt of S-(?)-betaxolol of formula (1).
Synthesis of a series of compounds related to betaxolol, a new β1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases
Manoury,Binet,Rousseau,Lefevre-Borg,Cavero
, p. 1003 - 1011 (2007/10/02)
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