63659-24-5

Upstream product

• 7051-34-5 cyclopropylcarbinyl bromide 
• 123-31-9 hydroquinone 
• 164520-99-4 4-(cyclopropylmethoxy)benzaldehyde 

Downstream Products

• 63659-25-6 1-[4-(cyclopropylmethoxy)phenoxy]-2,3-epoxy-propane 
• 1446007-23-3 (S)-(1-{4-[3-(4-cyclopropylmethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-carbamic acid tert-butyl ester 
• 860616-68-8 2-chloro-4-cyclopropylmethoxy-phenol 
• 1446007-96-0 N-(1-{4-[3-(4-cyclopropylmethoxy-phenoxy)-azetidin-1-yl]-phenyl}-1-methyl-ethyl)-acetamide 
• 1446008-12-3 (S)-1-{4-[3-(4-cyclopropylmethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethylamine 
• 1446008-06-5 3-(4-cyclopropylmethoxy-phenoxy)-azetidine 
• 1446008-07-6 3-(4-cyclopropylmethoxy-phenoxy)-azetidine-1-carboxylic acid tert-butyl ester 
• 860616-47-3 1-(3-bromo-propoxy)-2-chloro-4-cyclopropylmethoxy-benzene 

Relevant academic research and scientific papers

General method for the synthesis of salicylic acids from phenols through palladium-catalyzed silanol-directed C-H carboxylation

A silanol-directed, palladium-catalyzed C-H carboxylation reaction of phenols to give salicylic acids has been developed. This method features high efficiency and selectivity, and excellent functional-group tolerance. The generality of this method was demonstrated by the carboxylation of estrone and by the synthesis of an unsymmetrically o,o′-disubstituted phenolic compound through two sequential C-H functionalization processes.

(2R)-2-Methylchromane-2-carboxylic acids: Discovery of selective PPARα agonists as hypolipidemic agents

A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARα agonisim. As a result, highly potent, and selective PPARα agonists were discovered. The optimized compound 43 exhibited robust lowering of total cholesterol levels in hamster and dog animal models.

ANTIHYPERTENSIVE 3-(UREIDOCYCLOHEXYLENEAMINO)PROPANE-1,2-DIOL DERIVATIVES

Certain 3-(ureidocyclohexyleneamino)propane-1,2-diol derivatives, such as the compounds of formula III below, represent novel and useful pharmaceutical agents, e.g. potent antihypertensive and cardioactive agents demonstrating both α-and β-adrenergic bloc