636592-82-0Relevant academic research and scientific papers
Total regio- and stereoselective synthesis of perhydropyrrolo[3,4-c]pyrazole derivatives by [3+2] intramolecular dipolar cycloaddition reaction on chiral perhydro-1,3-benzoxazines
Pedrosa, Rafael,Andres, Celia,Maestro, Alicia,Nieto, Javier
, p. 1457 - 1461 (2007/10/03)
Reaction of N-acyl-N′-methyl- or N-acyl-N′-phenylhydrazines with chiral 3-allyl-2-formylperhydro-1,3-benzoxazines form azomethine imines that cyclize to give perhydropyrrolo[3,4-c]pyrazole derivatives. The dipolar cycloaddition was totally regio- and stereoselective yielding a single diastereoisomer. The reaction conditions and the yields of the final compounds are dependent on the substitution pattern of the olefinic bond.
