63675-90-1

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 7250-67-1 1-(2-chloroethyl)pyrrolidine hydrochloride 
• 63675-89-8 methyl 4-<2-(1-pyrrolidinyl)ethoxy>benzoate 

Downstream Products

• 63675-91-2 4-[2-(1-pyrrolidinyl)ethoxy]benzoyl chloride 
• 215656-53-4 4-[2-(1-pyrrolidinyl)ethoxy]benzamide 
• 84449-69-4 <6-(benzoyloxy)-2-<4-(benzoyloxy)phenyl>benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride 
• 84449-67-2 <6-acetoxy-2-(4-acetoxyphenyl)benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride 
• 84449-70-7 6-methanesulfonyloxy-2-(4-methanesulfonyloxyphenyl)-3-[4-(2-pyrrolidinoethoxy)benzoyl]benzo[b]thiophene, hydrochloride 
• 193966-21-1 2-(4-Methoxyphenyl)benzofuran-3-yl 4-[2-(1-Pyrrolidinyl)ethoxy]phenyl Ketone 

Relevant academic research and scientific papers

4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS

The present invention covers 4-(3-amino-6-fluoro-1H-indazol-5-yl)-1,2,6-trimethyl-1,4- dihydropyridine-3,5-dicarbonitrile compounds of general formula (I) : in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases.

Antithrombotic agents

The invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.