63697-67-6

Basic information

• Product Name: 2-[2-(pyridin-3-ylmethylidene)hydrazinyl]pyridine
• CAS NO: 63697-67-6
• Molecular Formula: C₁₁H₁₀N₄
• Molecular Weight: 198.2239
• Mol File: 63697-67-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 378°C at 760 mmHg
• Flash Point: 182.4°C
• Density: 1.15g/cm³
• Vapor Pressure: 6.48E-06mmHg at 25°C
• Refractive Index: 1.621
• CAS DataBase Reference: 2-[2-(pyridin-3-ylmethylidene)hydrazinyl]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(pyridin-3-ylmethylidene)hydrazinyl]pyridine(63697-67-6)
• EPA Substance Registry System: 2-[2-(pyridin-3-ylmethylidene)hydrazinyl]pyridine(63697-67-6)

Safety Data

• Hazardous Substances Data: 63697-67-6(Hazardous Substances Data)

Usage

Structure

Consists of two pyridine rings connected by a hydrazine and hydrazide functional groups

Use

Commonly used in research and industrial applications as a building block for the synthesis of new compounds or as a reagent in organic chemistry reactions

Potential biological/pharmacological activities

Not extensively studied, but may have potential effects in this area

Unique properties

Valuable tool in the development of new materials and pharmaceuticals due to its unique structure and reactivity.

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 4930-98-7 pyrid-2-ylhydrazine 
• 100-54-9 pyridine-3-carbonitrile 

Relevant articles and documents

Synthesis, Biological Activity, and Mechanism of Action of 2-Pyrazyl and Pyridylhydrazone Derivatives, New Classes of Antileishmanial Agents

In this work, we report the antileishmanial activity of 23 compounds based on 2-pyrazyl and 2-pyridylhydrazone derivatives. The compounds were tested against the promastigotes of Leishmania amazonensis and L. braziliensis, murine macrophages, and intracellular L. amazonensis amastigotes. The most potent antileishmanial compound was selected for investigation into its mechanism of action. Among the evaluated compounds, five derivatives [(E)-3-((2-(pyridin-2-yl)hydrazono)methyl)benzene-1,2-diol (2 b), (E)-4-((2-(pyridin-2-yl)hydrazono)methyl)benzene-1,3-diol (2 c), (E)-4-nitro-2-((2-(pyrazin-2-yl)hydrazono)methyl)phenol (2 s), (E)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)pyrazine (2 u), and (E)-2-(2-((5-nitrofuran-2-yl)methylene)hydrazinyl)pyrazine (2 v)] exhibited significant activity against L. amazonensis amastigote forms, with IC50 values below 20 μm. The majority of the compounds did not show any toxic effect on murine macrophages. Preliminary studies on the mode of action of members of this hydrazine-derived series indicate that the accumulation of reactive oxygen species (ROS) and disruption of parasite mitochondrial function are important for the pharmacological effect on L. amazonensis promastigotes.

Potential anticonvulsant. XII. Anticonvulsant activity of some aldehyde derivatives

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