637-87-6

Basic information

• Product Name: 1-Chloro-4-iodobenzene
• Synonyms: Chloro-4-iodobenz;1-Chloro-4-iodobenzene, 97+%;P-IODOCHLOROBENZENE;P-CHLOROIODOBENZENE;1-chloro-4-iodo-benzen;4-Iodochlorobenzene;benzene,1-chloro-4-iodo-;p-chlorophenyliodide
• CAS NO: 637-87-6
• Molecular Formula: C₆H₄ClI
• Molecular Weight: 238.45
• EINECS: 211-305-5
• Product Categories: Chlorine Compounds;Iodine Compounds;White to light yellowcrystalline powder;Aryl;C6;Halogenated Hydrocarbons
• Mol File: 637-87-6.mol
• Article Data: 126

Chemical Properties

• Melting Point: 53-54 °C(lit.)
• Boiling Point: 226-227 °C(lit.)
• Flash Point: 227 °F
• Appearance: Off-white to light beige/Crystalline Powder or Crystals
• Density: 1.8860
• Vapor Pressure: 0.119mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
• Sensitive: Light Sensitive
• BRN: 1634414
• CAS DataBase Reference: 1-Chloro-4-iodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-4-iodobenzene(637-87-6)
• EPA Substance Registry System: 1-Chloro-4-iodobenzene(637-87-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 36/37-24/25
• WGK Germany: 3
• TSCA: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 637-87-6(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

Different sources of media describe the Uses of 637-87-6 differently. You can refer to the following data:
1. suzuki reaction
2. 4-Chloroiodobenzene is used as a reagent in the synthesis of Clothiapine (C588550); an atypical antipsychotic of the dibenzothiazepine chemical class that has shown efficacy in treatment-resistant schizophrenic patients.

Purification Methods

Distil it in a vacuum then recrystallise it from EtOH. [Sugden J Chem Soc 1173 1924, Beilstein 5 H 221, 5 III 579, 5 IV 695.]

InChI:InChI=1/C6H4ClI/c7-5-1-3-6(8)4-2-5/h1-4H

Upstream product

• 591-50-4 iodobenzene 
• 932-72-9 (Dichloroiodo)benzene 
• 107-18-6 allyl alcohol 
• 540-37-4 p-aminoiodobenzene 
• 52010-59-0 1-(4-chlorophenyl)-3,3-diethyltriaz-1-ene 
• 626-62-0 Cyclohexyl iodide 
• 53486-30-9 4-chlorobenzenediazonium sulfate 
• 201230-82-2 carbon monoxide 
• 16825-76-6 1-iodyl-4-chlorobenzene 
• 10557-71-8 4-chlorophenyltrimethylsilane 
• 108-90-7 chlorobenzene 
• 108-95-2 phenol 
• 76-05-1 trifluoroacetic acid 
• 2712-78-9 bis-[(trifluoroacetoxy)iodo]benzene 

Downstream Products

• 19264-71-2 9-(4-chlorophenyl)-9H-carbazole 
• 16012-40-1 4,4',4-trichlorotriphenylamine 
• 2146-79-4 di-p-chlorophenylmercury 
• 55258-74-7 C₁₅H₁₅ClO 
• 25444-41-1 1,3-Bis-<4-chlor-phenyl>-perfluor-propan 
• 69626-55-7 1-Chloro-4-((E)-4-methoxy-but-3-en-1-ynyl)-benzene 
• 10304-75-3 4-chloro(dichloroiodo)benzene 
• 181957-03-9 (4-chlorophenyl)boric anhydride 
• 1679-18-1 4-Chlorophenylboronic acid 
• 30101-14-5 (4-chlorophenyl)diiodoborane 
• 73350-59-1 (E)-1-chloro-4-(hex-1-en-1-yl)benzene 
• 64634-58-8 4.4'-Dichloro-4''fluorotriphenylamin 
• 126435-92-5 1-(4-chlorophenyl)-2-butanol 
• 5172-02-1 1-chloro-4-(2-phenylethynyl)benzene 

Relevant articles and documents

-

-

The graphite-catalyzed: ipso -functionalization of arylboronic acids in an aqueous medium: metal-free access to phenols, anilines, nitroarenes, and haloarenes

An efficient, metal-free, and sustainable strategy has been described for the ipso-functionalization of phenylboronic acids using air as an oxidant in an aqueous medium. A range of carbon materials has been tested as carbocatalysts. To our surprise, graphite was found to be the best catalyst in terms of the turnover frequency. A broad range of valuable substituted aromatic compounds, i.e., phenols, anilines, nitroarenes, and haloarenes, has been prepared via the functionalization of the C-B bond into C-N, C-O, and many other C-X bonds. The vital role of the aromatic π-conjugation system of graphite in this protocol has been established and was observed via numerous analytic techniques. The heterogeneous nature of graphite facilitates the high recyclability of the carbocatalyst. This effective and easy system provides a multipurpose approach for the production of valuable substituted aromatic compounds without using any metals, ligands, bases, or harsh oxidants.

A convenient synthetic approach to a novel class of aryldifluoromethyl pyrimidine derivatives containing strobilurin motif as insecticidal agents

A series of aryldifluoromethyl pyrimidine compounds containing strobilurin were synthesized through bioelectronic isometric design with azoxystrobin as the lead compound and a convenient approach to aryldifluoromethylpyrimidine intermediates was developed, which features mild reaction conditions and simple operation. The title compounds and aryldifluoromethylpyrimidine intermediates were characterized by NMR and HRMS. Both 7c and 7l of the preliminary screening tests showed 100% inhibition against Mythimna separata at 100 mg/L. At 20 mg/L, the lethal rate of 7l against Mythimna separata can be up to 80%.