637001-67-3

Basic information

• Product Name: (S,E)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-phenylpent-2-enoic acid
• CAS NO: 637001-67-3
• Molecular Weight: 413.473
• Mol File: 637001-67-3.mol

Chemical Properties

• CAS DataBase Reference: (S,E)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-phenylpent-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S,E)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-phenylpent-2-enoic acid(637001-67-3)
• EPA Substance Registry System: (S,E)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-phenylpent-2-enoic acid(637001-67-3)

Safety Data

• Hazardous Substances Data: 637001-67-3(Hazardous Substances Data)

Upstream product

• 139545-04-3 [L-(trans)]-4-[(t-butoxycarbonyl)amino]-5-phenyl-2-pentenoic acid 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 267008-78-6 (E)-(S)-4-Amino-5-phenyl-pent-2-enoic acid 
• 124818-94-6 ethyl (2E,4S)-4-[(tert-butoxycarbonyl)amino]-5-phenylpent-2-enoate 

Relevant articles and documents

Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

Design, synthesis and single-crystal conformations of hybrid triple-stranded β-sheets composed of E-vinylogous residues are reported. Restricting conformational flexibility of β-strands through the insertion of carbon-carbon double bonds at facing positio

Self-assembly to function: Design, synthesis, and broad spectrum antimicrobial properties of short hybrid e -vinylogous lipopeptides

Nonribosomal E-vinylogous γ-amino acids are widely present in many peptide natural products and have been exploited as inhibitors for serine and cysteine proteases. Here, we are reporting the broad spectrum antimicrobial properties and self-assembled nanostructures of various hybrid lipopeptides composed of 1:1 alternating α- and E-vinylogous residues. Analysis of the results revealed that self-assembled nanostructures also play a significant role in the antimicrobial and hemolytic activities. In contrast to the α-peptide counterparts, vinylogous hybrid peptides displayed excellent antimicrobial properties against various bacterial and fungal strains. Peptides that adopted nanofiber structures displayed less hemolytic activity, while peptides that adopted nanoneedle structures displayed the highest hemolytic activity.