637024-85-2Relevant articles and documents
Aminoethylenes: A tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1
Yang, Wenjin,Lu, Wanli,Lu, Yafan,Zhong, Min,Sun, Jian,Thomas, Anila E.,Wilkinson, Jennifer M.,Fucini, Raymond V.,Lam, Melissa,Randal, Mike,Shi, Xiao-Ping,Jacobs, Jeffrey W.,McDowell, Robert S.,Gordon, Eric M.,Ballinger, Marcus D.
, p. 839 - 842 (2007/10/03)
A series of novel β-site amyloid precursor protein cleaving enzyme (BACE-1) inhibitors containing an aminoethylene (AE) tetrahedral intermediate isostere were synthesized and evaluated in comparison to corresponding hydroxyethylene (HE) compounds. Enzymat