637027-24-8

Basic information

• Product Name: (R)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester
• Synonyms: (R)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester;1,2,4-Piperazinetricarboxylic acid, 1,4-bis(1,1-diMethylethyl) 2-Methyl ester, (2R)-;(R)-1,4-Di-tert-butyl 2-Methyl piperazine-1,2,4-tricarboxylate
• CAS NO: 637027-24-8
• Molecular Formula: C₁₆H₂₈N₂O₆
• Molecular Weight: 344.40332
• Mol File: 637027-24-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 406.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.145±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.27±0.70(Predicted)
• CAS DataBase Reference: (R)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester(637027-24-8)
• EPA Substance Registry System: (R)-1,4-di-Boc-piperazine-2-carboxylic acid Methyl ester(637027-24-8)

Safety Data

• Hazardous Substances Data: 637027-24-8(Hazardous Substances Data)

Usage

General Description

(R)-1,4-di-Boc-piperazine-2-carboxylic acid methyl ester is a specific chemical compound often used in the synthesis of pharmaceutical drugs and organic molecules. It is an ester derivative of piperazine, a heterocyclic organic compound with a six-membered ring containing two nitrogen atoms. The compound is commonly utilized in the preparation of various drug candidates and molecules with biological activity. Its precise chemical structure and properties make it a valuable intermediate in organic synthesis, particularly in the pharmaceutical industry, where it plays a crucial role in the development of new medications and treatments for various medical conditions. Its chemical composition and function make it an essential component in the production of cutting-edge pharmaceutical compounds.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 252990-05-9 1-(tert-butyl) 2-methyl (R)-piperazine-1,2-dicarboxylate 
• 279227-92-8 (R)-1-N-Boc-piperazine-2-carboxylic acid methyl ester hydrochloride 
• 173774-48-6 (R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 173774-48-6 (R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester 
• 1589081-62-8 (R)-2-benzoylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 1589081-63-9 (R)-2-(hydroxyphenylmethyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 1589081-64-0 (R)-2-(fluorophenylmethyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 1589081-66-2 (R)-2-(4-fluorobenzoyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 1589081-67-3 (R)-2-[(4-fluorophenyl)hydroxymethyl]piperazine-1,4-dicarboxylic acid di-tert-butyl ester 

Relevant articles and documents

ANTAGONISTS OF THE ADENOSINE A2A RECEPTOR

The present invention relates to compounds of formula I shown below: wherein R0, R1, R2, R3 and A are each as defined in the application. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or conditions in which adenosine A2a receptor activity is implicated, such as, for example, cancer.

Human Adam-10 Inhibitors

Magnesium salts/complexes of compounds useful for inhibiting the ADAM-IO protein and methods of making and purifying them are provided. Further provided are compositions comprising magnesium salts/complexes of the compounds in combination with a pharmaceutically acceptable carrier. The compounds well as such compositions comprising them are useful for the treatment of cancer, arthritis, diseases related to angiogenesis, such as renal diseases, heart diseases, such as heart failure, atherosclerosis, and stroke, inflammation, ulcer, infertility, scleroderma, endometriosis, mesothelioma, and diabetes. In addition, methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role are provided.