637031-88-0

Basic information

• Product Name: 3,3-DIFLUOROCYCLOBUTANOL
• Synonyms: 3,3-DIFLUOROCYCLOBUTANOL;3,3-difluorocyclobutan-1-ol;Cyclobutanol, 3,3-difluoro-;3,3-Difluorocyclobutanol - D11666
• CAS NO: 637031-88-0
• Molecular Formula: C₄H₆F₂O
• Molecular Weight: 108.0866464
• Mol File: 637031-88-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 108.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 13.36±0.40(Predicted)
• CAS DataBase Reference: 3,3-DIFLUOROCYCLOBUTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-DIFLUOROCYCLOBUTANOL(637031-88-0)
• EPA Substance Registry System: 3,3-DIFLUOROCYCLOBUTANOL(637031-88-0)

Safety Data

• RIDADR: UN1993
• Hazardous Substances Data: 637031-88-0(Hazardous Substances Data)

Usage

Uses

3,?3-?Difluorocyclobutanol is a starting material and useful building block of various pharmaceuticals.

InChI:InChI=1S/C4H6F2O/c5-4(6)1-3(7)2-4/h3,7H,1-2H2

Upstream product

• 637031-86-8 (3,3-difluorocyclobutoxymethyl)benzene 

Downstream Products

• 637031-90-4 4-(3,3-difluorocyclobutoxy)-5-methanesulfonyl-2-methylbenzoic acid methyl ester 
• 1273564-99-0 3,3-difluorocyclobutan-1-one 
• 1618664-00-8 4-(2-chloro-4-(3,3-difluorocyclobutoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide 

Relevant articles and documents

Multigram Synthesis of C 4/C5 3,3-Difluorocyclobutyl-Substituted Building Blocks

An approach for the multigram synthesis of 3,3-difluorocyclobutyl-substituted building blocks (including carboxylic acid, amines, alcohols, azide, trifluoroborate ketone) is described. It is shown that, in most cases, ethyl 3,3-difluorocyclobutanecarboxylate is a convenient common synthetic intermediate to obtain the target derivatives. For preparation of 3,3-difluorocyclobutanol or -cyclobutanone, an alternative pathway via reaction of dichloroketene and tert -butyl or benzyl vinyl ether should be applied.