637035-41-7

Basic information

• Product Name: (5S)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-1-(4,5-dimethoxy-2-nitro-benzoyl)pyrrolidin-3-one
• Synonyms: (5S)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-1-(4,5-dimethoxy-2-nitro-benzoyl)pyrrolidin-3-one
• CAS NO: 637035-41-7
• Molecular Weight: 438.553
• Mol File: 637035-41-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (5S)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-1-(4,5-dimethoxy-2-nitro-benzoyl)pyrrolidin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5S)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-1-(4,5-dimethoxy-2-nitro-benzoyl)pyrrolidin-3-one(637035-41-7)
• EPA Substance Registry System: (5S)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-1-(4,5-dimethoxy-2-nitro-benzoyl)pyrrolidin-3-one(637035-41-7)

Safety Data

• Hazardous Substances Data: 637035-41-7(Hazardous Substances Data)

Upstream product

• 260417-86-5 (5S)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-1-(4,5-dimethoxy-2-nitro-benzoyl)pyrrolidin-3-ol 
• 260417-94-5 (2S,4R)-2-tert-butyldimethylsilyloxymethyl-4-hydroxypyrrolidine 
• 4998-07-6 4,5-dimethoxy-2-nitro-benzoic acid 

Downstream Products

• 637035-43-9 (S)-5-((tert-butyldimethylsilyloxy)methyl)-1-(4,5-dimethoxy-2-nitrobenzoyl)-2,5-dihydro-1H-pyrrol-3-yl trifluoromethanesulfonate 
• 637035-46-2 (S)-allyl 2-(2-((tert-butyldimethylsilyloxy)methyl)-4-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-1-carbonyl)-4,5-dimethoxyphenylcarbamate 
• 637035-47-3 (S)-allyl 2-(2-(hydroxymethyl)-4-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-1-carbonyl)-4,5-dimethoxyphenylcarbamate 
• 637035-44-0 (S)-(2-((tert-butyldimethylsilyloxy)methyl)-4-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-1-yl)(4,5-dimethoxy-2-nitrophenyl)methanone 
• 637035-45-1 (S)-(2-amino-4,5-dimethoxyphenyl)(2-((tert-butyldimethylsilyloxy)methyl)-4-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-1-yl)methanone 
• 637035-48-4 (11S,11aS)-allyl 11-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-5-oxo-11,11a-dihydro-3H-pyrrolo[2,1-c][1,4]benzodiazepine-10(5H)-carboxylate 

Relevant articles and documents

PYRROLOBENZODIAZEPINE ANTIBODY DRUG CONJUGATES AND METHODS OF USE

The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, pyrrolobenzodiazepine linker-drug intermediates, and methods of using the antibody-drug conjugates.

Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine.

A novel C2-aryl 1,2-unsaturated PBD (14) has been prepared via an enol triflate intermediate (8). The regiochemistry of triflation is dependent upon the point at which the reaction is performed during the synthetic route.