637035-41-7

Upstream product

• 260417-94-5 (2S,4R)-2-tert-butyldimethylsilyloxymethyl-4-hydroxypyrrolidine 
• 4998-07-6 4,5-dimethoxy-2-nitro-benzoic acid 
• 260417-86-5 (5S)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-1-(4,5-dimethoxy-2-nitro-benzoyl)pyrrolidin-3-ol 

Downstream Products

• 637035-43-9 (S)-5-((tert-butyldimethylsilyloxy)methyl)-1-(4,5-dimethoxy-2-nitrobenzoyl)-2,5-dihydro-1H-pyrrol-3-yl trifluoromethanesulfonate 
• 637035-48-4 (11S,11aS)-allyl 11-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-5-oxo-11,11a-dihydro-3H-pyrrolo[2,1-c][1,4]benzodiazepine-10(5H)-carboxylate 
• 637035-45-1 (S)-(2-amino-4,5-dimethoxyphenyl)(2-((tert-butyldimethylsilyloxy)methyl)-4-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-1-yl)methanone 
• 637035-44-0 (S)-(2-((tert-butyldimethylsilyloxy)methyl)-4-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-1-yl)(4,5-dimethoxy-2-nitrophenyl)methanone 
• 637035-47-3 (S)-allyl 2-(2-(hydroxymethyl)-4-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-1-carbonyl)-4,5-dimethoxyphenylcarbamate 
• 637035-46-2 (S)-allyl 2-(2-((tert-butyldimethylsilyloxy)methyl)-4-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-1-carbonyl)-4,5-dimethoxyphenylcarbamate 

Relevant academic research and scientific papers

PYRROLOBENZODIAZEPINE ANTIBODY DRUG CONJUGATES AND METHODS OF USE

The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, pyrrolobenzodiazepine linker-drug intermediates, and methods of using the antibody-drug conjugates.

Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1- c ][1,4]benzodiazepine (PBD) antitumor agents

A comprehensive SAR investigation of the C2-position of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) monomer antitumor agents is reported, establishing the molecular requirements for optimal in vitro cytotoxicity and DNA-binding affinity. Both carbocyclic and

Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine.

A novel C2-aryl 1,2-unsaturated PBD (14) has been prepared via an enol triflate intermediate (8). The regiochemistry of triflation is dependent upon the point at which the reaction is performed during the synthetic route.