637042-30-9

Basic information

• Product Name: Benzoic acid, 2-[[2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]thio]-
• CAS NO: 637042-30-9
• Molecular Formula: C17H12F3NO3S
• Molecular Weight: 367.348
• Mol File: 637042-30-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-[[2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[[2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]thio]-(637042-30-9)
• EPA Substance Registry System: Benzoic acid, 2-[[2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]thio]-(637042-30-9)

Safety Data

• Hazardous Substances Data: 637042-30-9(Hazardous Substances Data)

Upstream product

• 133115-55-6 [3-(trifluoromethoxy)phenyl]hydrazine hydrochloride 
• 336186-19-7 2-(2-oxopropylmercapto)benzoic acid 

Downstream Products

• 57330-25-3 [3-(4-chloro-benzoyl)-2-methyl-6-trifluoromethoxy-indol-1-yl]-acetic acid methyl ester 
• 57329-72-3 [3-(4-chloro-benzoyl)-2-methyl-6-trifluoromethoxy-indol-1-yl]-acetic acid 
• 57330-37-7 (4-chlorophenyl)[2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]methanone 
• 637042-53-6 C₂₈H₂₅ClF₃N₃O₃S 
• 57330-49-1 2-methyl-6-(trifluoromethoxy)-1H-indole 

Relevant articles and documents

Discovery of a peroxisome proliferator activated receptor γ (PPARγ) modulator with balanced PPARα activity for the treatment of type 2 diabetes and dyslipidemia

A series of 3-acylindole-1-benzylcarboxylic acids were designed and synthesized while searching for a PPARγ modulator with additional moderate intrinsic PPARα agonistic activity. 2-[3-[[3-(4-Chlorobenzoyl)-2-methyl- 6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy]-(2R)-butanoic acid (12d) was identified as such an agent which demonstrated potent efficacy in lowering both glucose and lipids in multiple animal models with significantly attenuated side effects such as fluid retention and heart weight gain associated with PPARγ full agonists. The moderate PPARα activity of 12d not only contributed to the agent's ability to manage lipid profiles but also appears to have potentiated its PPARγ efficacy in lowering glucose levels in preclinical diabetic animal models.

INDOLES HAVING ANTI-DIABETIC ACTIVITY

Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.