63710-33-8

Basic information

• Product Name: 3-Bromo-N-phenylbenzamide
• Synonyms: 3-Bromo-N-phenylbenzamide;3-BROMOBENZANILIDE
• CAS NO: 63710-33-8
• Molecular Formula: C₁₃H₁₀BrNO
• Molecular Weight: 276.13
• Product Categories: blocks;Bromides;Carboxes
• Mol File: 63710-33-8.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 305.718°C at 760 mmHg
• Flash Point: 138.694°C
• Appearance: /
• Density: 1.497g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.665
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-Bromo-N-phenylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-N-phenylbenzamide(63710-33-8)
• EPA Substance Registry System: 3-Bromo-N-phenylbenzamide(63710-33-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 63710-33-8(Hazardous Substances Data)

Usage

General Description

3-Bromo-N-phenylbenzamide is a chemical compound with the molecular formula C13H10BrNO. It is a benzamide derivative with a bromine atom attached to the carbon in the 3-position of the benzene ring. 3-Bromo-N-phenylbenzamide is commonly used in organic synthesis and pharmaceutical research due to its potential as a building block in the development of new drugs. It is also known for its ability to inhibit certain enzymes and could have potential applications in the field of medicine. 3-Bromo-N-phenylbenzamide is a white crystalline solid at room temperature and has a melting point of around 210-212°C. It is important to handle this compound with caution as it may be harmful if ingested or inhaled and could cause irritation to the skin and eyes.

InChI:InChI=1/C13H10BrNO/c14-11-6-4-5-10(9-11)13(16)15-12-7-2-1-3-8-12/h1-9H,(H,15,16)

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 591-50-4 iodobenzene 
• 22726-00-7 3-bromobenzamide 
• 314767-38-9 (1H-benzo[d][1,2,3]triazol-1-yl)(3-bromophenyl)methanone 
• 98-95-3 nitrobenzene 
• 95-14-7 1,2,3-Benzotriazole 
• 1711-09-7 3-bromobenzoyl chloride 
• 1016-77-9 3-bromobenzophenone 
• 62-53-3 aniline 
• 585-76-2 m-bromobenzoic acid 
• 103-84-4 Acetanilid 
• 591-18-4 1-Bromo-3-iodobenzene 
• 201230-82-2 carbon monoxide 
• 89598-96-9 (3-bromophenyl)boronic acid 

Downstream Products

• 127351-07-9 3-Bromo-N-phenyl-thiobenzamide 
• 1382354-08-6 2-(3-N-methyl-N-phenylbenzamidoamino)benzamide 
• 1382354-07-5 C₂₀H₁₇N₃O₂ 
• 229479-44-1 3-bromo-N-methyl-N-phenylbenzamide 
• 19654-14-9 2-(3-Bromo-phenyl)-benzothiazole 
• 25110-51-4 3-bromo-N,N'-diphenyl-benzamidine 
• 26704-93-8 3-bromo-4'-dimethylamino-benzophenone 
• 96462-76-9 3-bromo-benzoic acid-(N-nitroso-anilide) 
• 69873-73-0 3-bromo-N-phenyl-benzimidoyl chloride 

Relevant articles and documents

Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides

Herein we report a Ni-catalyzed reductive transamidation of conveniently available N-acyl benzotriazoles with alkyl, alkenyl, and aryl nitro compounds, which afforded various amides with good yields and a broad substrate scope. The same catalytic reaction conditions were also applicable for N-sulfonyl benzotriazoles, which could undergo smooth reductive coupling with nitroarenes and nitroalkanes to afford the corresponding sulfonamides.

COMPOUNDS AND METHODS OF INHIBITING BACTERIAL CHAPERONIN SYSTEMS

The present disclosure relates to novel compounds and methods of killing or inhibiting the growth of bacteria. In some embodiments, a method of killing or inhibiting the growth of bacteria is provided. The method comprises administering a compound of formula I or a pharmaceutically acceptable salt thereof to bacteria. In some embodiments, a method of killing or inhibiting the growth of bacteria is provided. The method comprises administering an anthelmintic to bacteria.

Highly Chemoselective, Transition-Metal-Free Transamidation of Unactivated Amides and Direct Amidation of Alkyl Esters by N-C/O-C Cleavage

The amide bond is one of the most fundamental functional groups in chemistry and biology and plays a central role in numerous processes harnessed to streamline the synthesis of key pharmaceutical and industrial molecules. Although the synthesis of amides is one of the most frequently performed reactions by academic and industrial scientists, the direct transamidation of tertiary amides is challenging due to unfavorable kinetic and thermodynamic contributions of the process. Herein, we report the first general, mild, and highly chemoselective method for transamidation of unactivated tertiary amides by a direct acyl N-C bond cleavage with non-nucleophilic amines. This operationally simple method is performed in the absence of transition metals and operates under unusually mild reaction conditions. In this context, we further describe the direct amidation of abundant alkyl esters to afford amide bonds with exquisite selectivity by acyl C-O bond cleavage. The utility of this process is showcased by a broad scope of the method, including various sensitive functional groups, late-stage modification, and the synthesis of drug molecules (>80 examples). Remarkable selectivity toward different functional groups and within different amide and ester electrophiles that is not feasible using existing methods was observed. Extensive experimental and computational studies were conducted to provide insight into the mechanism and the origins of high selectivity. We further present a series of guidelines to predict the reactivity of amides and esters in the synthesis of valuable amide bonds by this user-friendly process. In light of the importance of the amide bond in organic synthesis and major practical advantages of this method, the study opens up new opportunities in the synthesis of pivotal amide bonds in a broad range of chemical contexts.