Cas 63730-48-3,(-)-3-Methoxy Butorphanol

63730-48-3

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Basic information

Product Name: (-)-3-Methoxy Butorphanol
Synonyms: (-)-3-Methoxy Butorphanol;(-)-N-CyclobutylMethyl-14β-hydroxy-3-MethoxyMorphinan;17-(CyclobutylMethyl)-3-Methoxy-Morphinan-14-ol
CAS NO:63730-48-3
Molecular Formula: C22H31NO2
Molecular Weight: 341.48704
EINECS: N/A
Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 63730-48-3.mol
Article Data: 5

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: /
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (-)-3-Methoxy Butorphanol(CAS DataBase Reference)
NIST Chemistry Reference: (-)-3-Methoxy Butorphanol(63730-48-3)
EPA Substance Registry System: (-)-3-Methoxy Butorphanol(63730-48-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 63730-48-3(Hazardous Substances Data)

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63730-48-3 Usage

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Protected intermediate of Butorphanol.

Check Digit Verification of cas no

The CAS Registry Mumber 63730-48-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,7,3 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 63730-48:
(7*6)+(6*3)+(5*7)+(4*3)+(3*0)+(2*4)+(1*8)=123
123 % 10 = 3
So 63730-48-3 is a valid CAS Registry Number.

63730-48-3Upstream product

63730-48-3Downstream Products

63730-48-3Relevant articles and documents

Process of N-demethylating (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline

-

, (2008/06/13)

N-Alkyl allylic tertiary amines are dealkylated as illustrated by treatment of (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline in cold methylene chloride with m-chloroperbenzoic acid followed by the addition of aqueous ferrous chloride to provide a good yield of (+)-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline with substantial if not complete retention of optical activity. The product is an intermediate in a synthesis of the analgesic known as butorphanol.

Process for the preparation of 14-hydroxymorphinan derivatives

-

, (2008/06/13)

N-substituted-14-hydroxy-3-substituted-morphinan derivatives have been found to possess potent narcotic agonist or antagonist activity. In particular, the compound 3,14-dihydroxy-N-cyclobutylmethylmorphinan has been found to possess potent agonist/antagonist activity. A new and novel total synthesis for the preparation of these compounds is described herein.

Oxilorphan and butorphanol. Potent narcotic antagonists and nonaddicting analgesics in the 3,14 dihydroxymorphinan series. Part V

Monkovic,Wong,Pircio,et al.

, p. 3094 - 3102 (2007/10/10)

A series of 3,14 dihydroxymorphinans 8 was synthesized via a method of (a) acylation of 3 methoxy Δ84 morphinan 4a (b) stereospecific epoxidation of the resultant amides to β epoxides 5 (c) simultaneous reduction of amide and epoxide functions and (d) demethylation of the resultant 3 methoxy 14 hydroxymorphinans 7. Alternatively deblocking of the amine function in 5b by hydrolysis followed by reduction of the resultant amino epoxide 5e afforded 14 hydroxy 3 methoxymorphinan 7e, which is readily alkylated and demethylated to give various 8. On a basis of interesting pharmacological profiles compounds l 8c (oxilorphan) and l 8d (butorphanol) were selected for clinical studies.