637328-01-9Relevant academic research and scientific papers
Structure-activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor
Gallant, Michel,Belley, Michel,Carriere, Marie-Claude,Chateauneuf, Anne,Denis, Danielle,Lachance, Nicolas,Lamontagne, Sonia,Metters, Kathleen M.,Sawyer, Nicole,Slipetz, Deborah,Truchon, Jean Francois,Labelle, Marc
, p. 3813 - 3816 (2007/10/03)
Potent and selective ligands for the human EP3 prostanoid receptor are described. Triaryl compounds bearing an ortho-substituted propionic acid moiety were identified as potent EP3 antagonists based on the SAR described herein. The binding affinities of key compound on all eight human prostanoid receptors is reported.
