637341-60-7 Usage
General Description
5-FLUORO-3-(4-HYDROXY-BUTYL)-1,3-DIHYDRO-INDOL-2-ONE, also known as AG-024322, is a chemical compound with potential antineoplastic and antiangiogenic activities. It is a synthetic small molecule that inhibits the proliferation of endothelial cells and the formation of new blood vessels, thereby preventing the growth and spread of tumors. 5-FLUORO-3-(4-HYDROXY-BUTYL)-1,3-DIHYDRO-INDOL-2-ONE has been studied for its potential use in treating various types of cancer, particularly those that are dependent on angiogenesis for their growth and metastasis. Research has shown promising results in preclinical studies, and further investigation is ongoing to explore its therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 637341-60-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,7,3,4 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 637341-60:
(8*6)+(7*3)+(6*7)+(5*3)+(4*4)+(3*1)+(2*6)+(1*0)=157
157 % 10 = 7
So 637341-60-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H14FNO2/c13-8-4-5-11-10(7-8)9(12(16)14-11)3-1-2-6-15/h4-5,7,9,15H,1-3,6H2,(H,14,16)
637341-60-7Relevant articles and documents
Optimization of (arylpiperazinylbutyl)oxindoles exhibiting selective 5-HT7 receptor antagonist activity
Volk, Balázs,Gacsályi, István,Pallagi, Katalin,Poszávácz, László,Gy?n?s, Ildikó,Szabó, éva,Bakó, Tibor,Spedding, Michael,Simig, Gyula,Szénási, Gábor
scheme or table, p. 6657 - 6669 (2011/12/02)
A series of (arylpiperazinylbutyl)oxindoles as highly potent 5-HT 7 receptor antagonists has been studied for their selectivity toward the 5-HT1A receptor and α1-adrenoceptor. Several derivatives exhibited high 5-HT7
New One-Pot Synthesis of 3-Alkyl- and 3-(ω-Hydroxyalkyl)oxindoles from Isatins
Volk, Balazs,Simig, Gyula
, p. 3991 - 3996 (2007/10/03)
A new and efficient one-pot procedure has been developed for the synthesis of 3-alkyl- and 3-(ω-hydroxyalkyl)oxindoles from isatins by treatment with alcohols and diols in the presence of Raney nickel, under hydrogen atmosphere. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
