637352-78-4

Upstream product

• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 49844-90-8 4-Chloro-2-methylthiopyrimidine 
• 637352-77-3 2-methylsulfanyl-4-(4-trifluoromethylphenyl)-pyrimidine 

Downstream Products

• 637352-79-5 ethyl {4-[(butyl{4-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl}amino)methyl]-2-methylphenoxy}acetate 
• 637352-83-1 ethyl {2-methyl-4-[(propyl{4-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl}amino)methyl]phenoxy}acetate 
• 637352-81-9 ethyl {4-[((2-methoxyethyl){4-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl}amino)methyl]-2-methylphenoxy}acetate 
• 637353-30-1 ethyl {2-ethyl-4-[([2-(methyloxy)ethyl]{4-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl}amino)methyl]phenoxy}acetate 

Relevant academic research and scientific papers

NOVEL HETEROCYCLIC COMPOUNDS AS ANTIMALARIAL AGENTS

The invention relates to novel heterocyclic compounds of the Formula I. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of the Formula I and

CHEMICAL COMPOUNDS

A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, .Wherein:R1 and R2 are independently hydrogen or C1-3 alkyl;X represents a bond, CH2 or O;R3 and R4 are independently hydrogen, C1-6 alkyl, OCH3, CF3, allyl or halogen;X1 is CH2, SO2, or CO;R5 is -C1-6 alkyl (optionally substituted by C1-6alkoxy or C1-6alkylthio), -C2-6 alkenyl, -C0-6 alkyl phenyl (wherein the phenyl is optionally substituted by one or more CF3, halogen, C1-3 alkyl, C1-3 alkoxy), -COC1-6 alkyl, SO2C1-6 alkyl ;R6 is phenyl or a 6 membered heteroaryl group containing 1,2 or 3 N atoms wherein the phenyl or heteroaryl group is optionally substituted with 1, 2 or 3 moieties selected from the group consisting of C1-6 alkyl, halogen, -OC1-6 alkyl, -SO2C1-3 alkyl, phenyl (optionally substituted by one or more groups selected from halogen, CF3, C1-3 alkyl, OC1-3 alkyl, acetyl, CN).