63744-21-8

Usage

Uses

Used in Organic Chemistry:
3,5-Dibromo-imidazo[1,2-a]pyrazine is used as a synthetic building block for the creation of pharmaceutical compounds due to its unique structure and chemical properties. It provides a foundation for the development of new organic molecules with potential applications in various fields.
Used in Drug Discovery:
In the pharmaceutical industry, 3,5-Dibromo-imidazo[1,2-a]pyrazine is utilized as a precursor in the development of new materials and compounds. Its chemical properties make it a valuable component in the synthesis of potential drug candidates, contributing to the advancement of medicinal chemistry.
Used in Material Development:
3,5-Dibromo-imidazo[1,2-a]pyrazine is also being studied for its potential use in the development of new materials. Its unique structure and properties lend themselves to the creation of innovative materials with applications in various industries, including electronics, coatings, and more.
Overall, 3,5-Dibromo-imidazo[1,2-a]pyrazine is a versatile compound with a wide range of potential applications across different scientific and industrial fields, making it a valuable asset in the ongoing pursuit of new discoveries and advancements.

InChI:InChI=1/C6H3Br2N3/c7-4-1-9-3-6-10-2-5(8)11(4)6/h1-3H

Upstream product

• 274-79-3 imidazo[1,2-a]pyrazine 

Downstream Products

• 787590-51-6 (3-bromo-imidazo[1,2-a]pyrazin-8-yl)-(4-methoxy-phenyl)-amine 
• 1011472-00-6 C₁₈H₁₃BrN₄O 
• 1011472-03-9 C₁₅H₁₅BrN₄O₃ 
• 1011472-09-5 3-bromo-N-phenylimidazo[1,2-a]pyrazin-8-amine 
• 1011472-12-0 LG₂-77 
• 1011472-16-4 LG₂-91 
• 117718-92-0 8-amino-3-bromoimidazo<1,2-a>pyrazine 

Relevant academic research and scientific papers

Synthesis and Antibronchospastic Activity of 8-Alkoxy- and 8-(Alkylamino)imidazopyrazines

Theophylline still occupies a dominant place in asthma therapy.Unfortunatly its adverse central nervous system (CNS) stimulant effects can dramatically limit its use, and adjustments in the dosage are often needed.We have synthesized a new series of imidazopyrazine derivatives which are much more potent bronchodilators than theophylline in vivo and do not exhibit the CNS stimulatory profile.In vitro studies on isolated rat uterus and guinea pig trachea confirm the high potentialities of these derivatives. 6-Bromo-8-(methylamino)imidazopyrazine-3-carbonitrile (23) is identified as the most potent compound of the series.As i n the case of theophylline, phosphodiesterase inhibition appears unlikely to be the unique mechanism of the action of this series of heterocycles.

8-alkylaminoimidazo(1,2-a)pyrazines and derivatives, their preparation and their application in therapy

STR1 Novel 8-alkylamino-imidazo(1,2-a)pyrazines of formula (I) show advantages pharmacological activities. They can be used for medical products in human and veterinary therapy in the field of applications of antispasmodics, uterine relaxants, bronchodila

Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties

A series of imidazo[1,2-a]pyrazine derivatives was synthesized by condensation of α-halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospastic activities. On isolated atria, 5-bromoimidazo[1,2-a]pyrazine showed positive chronotropic and inotropic properties; the latter was associated with an increase in the cyclic AMP tissue concentration. Potentiation of the isoproterenol positive inotropic effect of 5-bromoimidazo[1,2-a]pyrazine and the lack of blockade of the 5-bromoimidazo[1,2-a]pyrazine positive inotropic effect by propranolol suggested phosphodiesterase-inhibiting properties.