63760-93-0Relevant academic research and scientific papers
Synthesis of first representatives of 3,3′-bi(6,8-dialkyl-2,4-dioxa- 6,8-diazabicyclo[3.3.0]octan-7-ones)
Sigachev, Andrey S.,Kravchenko, Angelina N.,Gazieva, Galina A.,Belyakov, Pavel A.,Kolotyrkina, Natal'ya G.,Lebedev, Oleg V.,Makhova, Nina N.,Lyssenko, Konstantin A.
, p. 1295 - 1302 (2006)
The first representatives of 3,3′-bi(2,4-dioxa-6,8-diazabicyclo[3.3. 0]octan-7-ones) have been synthesized by a reaction of glyoxal as form of 2,2′-bi(4,5-dihydroxy-1,3-dioxalane) with N,N′-dialkylureas. Their structures have been supported by X-ray analy
Synthesis of new chiral mono-, di-, tri-, and tetraalkylglycolurils
Kravchenko,Sigachev,Maksareva,Gazieva,Trunova,Lozhkin,Pivina,Il'in,Lyssenko,Nelyubina,Davankov,Lebedev,Makhova,Tartakovsky
, p. 691 - 704 (2007/10/03)
Two general procedures were developed for the synthesis of chiral N-mono-, N, N′-di-, N, N′ N″-tri-, and N, N′, N″, N′″-tetraalkylglycolurils based on the reactions of 4,5-dihydroxy-imidazolidin-2-ones or glyoxal with one or two moles of alkylureas, respectively, by acid catalysis. The reactions of N-monoalkyl- and N, N′-dialkylureas with glyoxal proceed regioselectively. The mechanism of these reactions was suggested and partly confirmed by quantum-chemical calculations and experimental data. The enantiomeric separation of some chiral glycolurils by chiral-phase HPLC was carried out for the first time.
