637738-92-2

Usage

Structure

A derivative of naphthalene with hydroxyl groups and an allyl ether functional group

Industrial applications

a. Precursor in the synthesis of other organic compounds
b. Building block in the production of polymers and resins

Potential uses

a. Organic synthesis
b. Medicinal chemistry

Precautions

Proper handling and safety measures should be taken to minimize health and safety risks

Upstream product

• 481-39-0 5-hydroxynaphtho-1,4-quinone 
• 637738-91-1 5-(allyloxy)-naphthalene-1,4-dione 

Relevant academic research and scientific papers

Synthesis of (+)-nocardione A - Use of formal radical cyclization onto a benzene ring

Juglone (7) was converted into enone 13; this underwent radical cyclization to afford 15, which was aromatized to 16 and elaborated into (+)-nocardione A (1), the enantiomer of the naturally-occurring tyrosine phosphatase inhibitor (-)-nocardione A (2).

Formal Radical Cyclization onto Benzene Rings: A General Method and Its Use in the Synthesis of ent-Nocardione A

An indirect method is described for effecting radical cyclization onto a benzene ring. Cross-conjugated dienones 6, which are readily prepared from phenols, undergo radical cyclization (6 → 7 → 8), and the products (8) are easily aromatized. The method ha