63775-95-1

Basic information

• Product Name: Cyclosporin B
• Synonyms: CYCLOSPORIN B;Ala2-cyclosporine;Antibiotic S 7481F2;Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alanyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl];(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Ala-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-);Cyclosporine IMpurity-B;7-L-Alaninecyclosporine A;Cyclosporin B (9CI)
• CAS NO: 63775-95-1
• Molecular Formula: C61H109N11O12
• Molecular Weight: 1188.58
• Product Categories: Intermediates & Fine Chemicals;Peptides;Pharmaceuticals
• Mol File: 63775-95-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 149-152°C
• Boiling Point: 1289.7°C at 760 mmHg
• Flash Point: 733.8°C
• Appearance: Amorphous white solid
• Density: 1.019g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.468
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.32±0.70(Predicted)
• CAS DataBase Reference: Cyclosporin B(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclosporin B(63775-95-1)
• EPA Substance Registry System: Cyclosporin B(63775-95-1)

Safety Data

• Hazardous Substances Data: 63775-95-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 63775-95-1 differently. You can refer to the following data:
1. Cyclosporin B is a minor analogue of the cyclosporin complex produced by a number of different fungal genera including Trichoderma, Tolypocladium, Fusarium, Nectria and Acremonium. Cyclosporin B possesses immunosuppressant and antifungal activities but has been much less extensively investigated than the major analogue, cyclosporin A.
2. An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

InChI:InChI=1/C61H109N11O12/c1-25-26-27-39(14)51(74)50-55(78)64-41(16)56(79)66(18)32-47(73)67(19)43(28-33(2)3)54(77)65-48(37(10)11)60(83)68(20)44(29-34(4)5)53(76)62-40(15)52(75)63-42(17)57(80)69(21)45(30-35(6)7)58(81)70(22)46(31-36(8)9)59(82)71(23)49(38(12)13)61(84)72(50)24/h25-26,33-46,48-51,74H,27-32H2,1-24H3,(H,62,76)(H,63,75)(H,64,78)(H,65,77)/b26-25+/t39?,40-,41+,42+,43+,44+,45+,46+,48+,49+,50-,51?/m1/s1