637767-24-9

Upstream product

• 637767-50-1 pent-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide 
• 591-80-0 pent-4-enoic acid 
• 321-97-1 (1R,2R)-pseudoephedrine 

Downstream Products

• 637767-30-7 (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (1S,2S)-3-methoxy-2-pent-4-enoylamino-1-phenyl-propyl ester 
• 637767-34-1 (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (1S,2R)-2-pent-4-enoylamino-1-phenyl-propyl ester 
• 637767-47-6 (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (S)-2-pent-4-enoylamino-1-phenyl-ethyl ester 
• 637767-42-1 Pent-4-enoic acid (S)-2-{[(1R,2R,5S,6S,7S)-2-(allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carbonyl]-amino}-2-phenyl-ethyl ester 
• 637767-38-5 (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (S)-1-methyl-2-pent-4-enoylamino-ethyl ester 
• 637767-56-7 (1R,2R,5S,6S,7S)-3-(4-Methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-2,6-dicarboxylic acid 2-(allyl-benzyl-amide) 6-[((S)-2-hydroxy-1-phenyl-ethyl)-amide] 
• 637767-44-3 (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid 

Relevant academic research and scientific papers

Stereochemical Control of Skeletal Diversity

(Equation presented) Substrates having appendages that pre-encode skeletal information (σ-elements) can be converted into products having distinct skeletons using a common set of reaction conditions. The sequential use of the Ugi 4CC-IMDA reaction, followed by allylation, hydrolysis, and acylation of a chiral amino alcohol appendage (σ-element), leads to substrates for a ROM/RCM or RCM reaction. The stereochemistry of the a-element and not its constitution controls the outcome of the pathway selected. This work illustrates the potential of linking stereochemical control to the challenging problem of skeletal diversity.