637767-52-3

Upstream product

• 591-80-0 pent-4-enoic acid 
• 51594-34-4 (1S,2S)-2-amino-3-methoxy-1-phenyl-1-propanol 

Downstream Products

• 637767-28-3 (1S,2S,5R,6R,7R)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (1S,2S)-3-methoxy-2-pent-4-enoylamino-1-phenyl-propyl ester 
• 637767-30-7 (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (1S,2S)-3-methoxy-2-pent-4-enoylamino-1-phenyl-propyl ester 

Relevant academic research and scientific papers

Stereochemical Control of Skeletal Diversity

(Equation presented) Substrates having appendages that pre-encode skeletal information (σ-elements) can be converted into products having distinct skeletons using a common set of reaction conditions. The sequential use of the Ugi 4CC-IMDA reaction, followed by allylation, hydrolysis, and acylation of a chiral amino alcohol appendage (σ-element), leads to substrates for a ROM/RCM or RCM reaction. The stereochemistry of the a-element and not its constitution controls the outcome of the pathway selected. This work illustrates the potential of linking stereochemical control to the challenging problem of skeletal diversity.