6378-11-6

Basic information

• Product Name: Chloridosulfurous acid ethyl ester
• Synonyms: Chloridosulfurous acid ethyl ester;Chlorosulfurous acid, ethyl ester;Einecs 228-948-2
• CAS NO: 6378-11-6
• Molecular Formula: C₂H₅ClO₂S
• Molecular Weight: 128.58
• EINECS: 228-948-2
• Mol File: 6378-11-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 175.5°C at 760 mmHg
• Flash Point: 60°C
• Appearance: /
• Density: 1.284
• Vapor Pressure: 1.53mmHg at 25°C
• Refractive Index: 1.4550
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly)
• Stability: Moisture Sensitive, Volatile
• CAS DataBase Reference: Chloridosulfurous acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Chloridosulfurous acid ethyl ester(6378-11-6)
• EPA Substance Registry System: Chloridosulfurous acid ethyl ester(6378-11-6)

Safety Data

• Hazardous Substances Data: 6378-11-6(Hazardous Substances Data)

Usage

Uses

Ethyl chlorosulfinate is synthesized from Thionyl Chloride (T367750), which is an inorganic compound used as a chemical reagent in chlorination reactions. Used in the production of biological agents including insecticides and pesticides. Also used in the preparation of pharmaceutical agents, such as CFTR potentiators, commonly used in the treatment of cyctic fibrocis.

InChI:InChI=1/C2H5ClO2S/c1-2-5-6(3)4/h2H2,1H3

Upstream product

• 64-17-5 ethanol 
• 20461-86-3 2,2-diethoxy acetic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 7719-09-7 thionyl chloride 
• 623-81-4 diethyl sulphite 
• 109509-91-3 thiosulfurous acid O-ethyl ester S-phenyl ester 
• 17796-35-9 thiosulfurous acid S-butyl ester O-ethyl ester 
• 68261-74-5 thiosulfurous acid O,S-diethyl ester 
• 10026-13-8 phosphorus pentachloride 

Downstream Products

• 10315-59-0 ethylmethylsulfite 
• 623-81-4 diethyl sulphite 
• 18748-28-2 isoamyl sulfite 
• 114331-59-8 (Ξ)-ethyl-((S)-1-phenyl-ethyl)-sulfite 
• 1859-03-6 ethyl benzenesulfinate 
• 103-69-5 N-ethyl-N-phenylamine 
• 222851-56-1 N-phenylsulfinylamine 
• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 
• 92474-83-4 sulfurous acid ethyl ester-benzyl ester 
• 2294-38-4 1-Ethylpyridinium chloride 
• 7719-09-7 thionyl chloride 
• 75-00-3 chloroethane 
• 10025-87-3 trichlorophosphate 
• 7647-01-0 hydrogenchloride 

Relevant articles and documents

Synthesis and Biological Evaluation of a Series of Novel Celastrol Derivatives with Amino Acid Chain

The synthesis of celastrol analogues containing amino acid ester at the C(29) position and their evaluation for cytotoxic activities in?vitro were reported. The MTT test showed that a set of derivatives with lower IC50 values than that of the positive control group cisplatin and the parent compound celastrol, which exhibited greater antiproliferative activities. The most potent title compounds 2a and 2e exhibited cytotoxic activities in?vitro against HeLa and A549 cell lines with IC50 values of 0.371 and 0.237?μm, 0.235 and 0.109?μm, respectively. The apoptosis assay demonstrated that 2a and 2e can induces of A549 cell apoptosis in low concentrations. These results showed that 2a and 2e may be promising for further research as antitumor agents.

On the esters of thiosulfurous acid.

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